Literature DB >> 1454022

Platypus envenomation--a painful learning experience.

P J Fenner1, J A Williamson, D Myers.   

Abstract

OBJECTIVE: To describe in detail for the first time, the clinical course and medical management of a significant human envenomation by the Australian platypus (Ornithorhynchus anatinus). CLINICAL FEATURES: A 57-year-old man was envenomated via two spur wounds to the right hand from each hind leg of a male platypus. Pain was immediate, sustained, and devastating; traditional first aid analgesic methods were ineffective. INTERVENTION AND OUTCOME: On admission to hospital, narcotics administered intravenously, both intermittently and by infusion, provided inadequate analgesia. A right wrist block was dramatically effective. After the blockade narcotic analgesic support was required for several days. The patient spent six days in hospital, and the envenomated area remained painful, swollen and with little movement for three weeks. Significant functional impairment of the hand persisted for three months, the cause of which is uncertain.
CONCLUSIONS: Male platypus venom remains largely unstudied. It produces savage local pain and marked local swelling, but no apparent tissue ischaemia. No antivenom is available; in its absence the only effective analgesia appears to be regional nerve blockade, when the envenomation site and available skills permit. Immobilisation assists.

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Year:  1992        PMID: 1454022     DOI: 10.5694/j.1326-5377.1992.tb141302.x

Source DB:  PubMed          Journal:  Med J Aust        ISSN: 0025-729X            Impact factor:   7.738


  11 in total

1.  Solution structure of a defensin-like peptide from platypus venom.

Authors:  A M Torres; X Wang; J I Fletcher; D Alewood; P F Alewood; R Smith; R J Simpson; G M Nicholson; S K Sutherland; C H Gallagher; G F King; P W Kuchel
Journal:  Biochem J       Date:  1999-08-01       Impact factor: 3.857

2.  Defensin-like peptide-2 from platypus venom: member of a class of peptides with a distinct structural fold.

Authors:  A M Torres; G M de Plater; M Doverskog; L C Birinyi-Strachan; G M Nicholson; C H Gallagher; P W Kuchel
Journal:  Biochem J       Date:  2000-06-15       Impact factor: 3.857

3.  Proteomics and deep sequencing comparison of seasonally active venom glands in the platypus reveals novel venom peptides and distinct expression profiles.

Authors:  Emily S W Wong; David Morgenstern; Ehtesham Mofiz; Sara Gombert; Katrina M Morris; Peter Temple-Smith; Marilyn B Renfree; Camilla M Whittington; Glenn F King; Wesley C Warren; Anthony T Papenfuss; Katherine Belov
Journal:  Mol Cell Proteomics       Date:  2012-08-16       Impact factor: 5.911

4.  A limited role for gene duplications in the evolution of platypus venom.

Authors:  Emily S W Wong; Anthony T Papenfuss; Camilla M Whittington; Wesley C Warren; Katherine Belov
Journal:  Mol Biol Evol       Date:  2011-08-03       Impact factor: 16.240

5.  Characterization of a C-type natriuretic peptide (CNP-39)-formed cation-selective channel from platypus (Ornithorhynchus anatinus) venom.

Authors:  J I Kourie
Journal:  J Physiol       Date:  1999-07-15       Impact factor: 5.182

6.  Gallinacin-3, an inducible epithelial beta-defensin in the chicken.

Authors:  C Zhao; T Nguyen; L Liu; R E Sacco; K A Brogden; R I Lehrer
Journal:  Infect Immun       Date:  2001-04       Impact factor: 3.441

7.  A Spur to Atavism: Placing Platypus Poison.

Authors:  Peter Hobbins
Journal:  J Hist Biol       Date:  2015-11       Impact factor: 1.326

8.  Novel venom gene discovery in the platypus.

Authors:  Camilla M Whittington; Anthony T Papenfuss; Devin P Locke; Elaine R Mardis; Richard K Wilson; Sahar Abubucker; Makedonka Mitreva; Emily S W Wong; Arthur L Hsu; Philip W Kuchel; Katherine Belov; Wesley C Warren
Journal:  Genome Biol       Date:  2010-09-29       Impact factor: 13.583

9.  Defensins and the convergent evolution of platypus and reptile venom genes.

Authors:  Camilla M Whittington; Anthony T Papenfuss; Paramjit Bansal; Allan M Torres; Emily S W Wong; Janine E Deakin; Tina Graves; Amber Alsop; Kyriena Schatzkamer; Colin Kremitzki; Chris P Ponting; Peter Temple-Smith; Wesley C Warren; Philip W Kuchel; Katherine Belov
Journal:  Genome Res       Date:  2008-05-07       Impact factor: 9.043

Review 10.  Cabinet of Curiosities: Venom Systems and Their Ecological Function in Mammals, with a Focus on Primates.

Authors:  Johanna E Rode-Margono; K Anne-Isola Nekaris
Journal:  Toxins (Basel)       Date:  2015-07-17       Impact factor: 4.546

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