| Literature DB >> 14536090 |
Ming Guo1, Christopher Aston, Scott A Burchett, Christine Dyke, Stanley Fields, S Johannes R Rajarao, Peter Uetz, Yuqi Wang, Kathleen Young, Henrik G Dohlman.
Abstract
In yeast Saccharomyces cerevisiae the G protein betagamma subunits (Ste4/Ste18) have long been known to transmit the signal required for mating. Here we demonstrate that GTPase-deficient mutants of Galpha (Gpa1) directly activate the mating response pathway. We also show that signaling by activated Gpa1 requires direct coupling to an RNA binding protein Scp160. These findings suggest an additional role for Gpa1 and reveal Scp160 as a component of the mating response pathway in yeast.Entities:
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Year: 2003 PMID： 14536090 DOI： 10.1016/s1097-2765(03)00307-1
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970