| Literature DB >> 14535817 |
Hongbin Zhai1, Shengjun Luo, Chengfeng Ye, Yongxiang Ma.
Abstract
8O-methylaphanorphine was synthesized from 4-methoxyphenylacetaldehyde in 36% overall yield and in nine steps, featuring the formation of ring B via a Friedel-Crafts alkylative cyclization with the concomitant stereospecific introduction of the benzylic quaternary carbon center. The current work constitutes an efficient enantioselective formal synthesis of 3-benzazepine marine alkaloid (-)-aphanorphine.Entities:
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Year: 2003 PMID： 14535817 DOI： 10.1021/jo0348726
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354