| Literature DB >> 14535786 |
Ho Young Song1, Jung Min Joo, Jung Won Kang, Dae-Shik Kim, Cheol-Kyu Jung, Hyo Shin Kwak, Jin Hyun Park, Eun Lee, Chang Yong Hong, ShinWu Jeong, Kiwan Jeon, Ji Hyun Park.
Abstract
The proposed structure of lasonolide A was synthesized employing radical cyclization reactions of beta-alkoxyacrylates for preparation of the tetrahydropyranyl units A and B, but the spectroscopic data did not match those of the natural product. Both enantiomers of a revised structure featuring 17E,25Z double bonds were synthesized, and the (-)-isomer was found to be the biologically active enantiomer.Entities:
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Year: 2003 PMID： 14535786 DOI： 10.1021/jo034930n
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354