Water exclusion reaction in aqueous media: nitrone formation and cycloaddition in a single pot.

[reaction: see text] The formation of nitrone (a water exclusion reaction) in aqueous media using surfactant and subsequent cycloaddition in the same pot, a new example of green chemistry, is reported. The control of regioselectivity favors the formation of trans-5-substituted isoxazolidine. This work not only may lead to an environmentally benign system but also will provide a new aspect of reactions in water.