OBJECTIVE: To observe the effect of 654-2 injection and "GanXian Tui Huang Recipe" on hepatic fibrosis with intractable jaundice. METHODS:60 patients were treated for 3 months and randomly divided into control group and experiment group. The experiment group was treated with 654-2 injection and "Gan Xian Tui Huang Recipe" and the control group was treated with routine treatment. All the patients have high level of Nitrogen monoxide(NO), hyaluronic acid(HA > 400 ng/ml) and hepatic fibrosis with intractable jaundice. RESULTS: In experiment group, the serum total bilirubin(TB), globulin(GLB), HA and NO were significantly decreased to normal level; 40% of portal veins were narrowed, 50% of them were not changed; 30% of spleen were thinned, 40% of them were fixed. 1 year later, 20 patients were stable and 2 patients were recurrent in 22 patients of the experiment group; in 24 patients of the control group, 7 patients were stable, 10 patients had hypersplenia, 2 patients occurred hepatocarcinoma and 5 patients were recurrent. CONCLUSION: Effect of 654-2 injection and "Gan Xian Tui Huang Recipe" on hepatic fibrosis with intractable jaundice is significant.
RCT Entities:
OBJECTIVE: To observe the effect of 654-2 injection and "GanXian Tui Huang Recipe" on hepatic fibrosis with intractable jaundice. METHODS: 60 patients were treated for 3 months and randomly divided into control group and experiment group. The experiment group was treated with 654-2 injection and "Gan Xian Tui Huang Recipe" and the control group was treated with routine treatment. All the patients have high level of Nitrogen monoxide(NO), hyaluronic acid(HA > 400 ng/ml) and hepatic fibrosis with intractable jaundice. RESULTS: In experiment group, the serum total bilirubin(TB), globulin(GLB), HA and NO were significantly decreased to normal level; 40% of portal veins were narrowed, 50% of them were not changed; 30% of spleen were thinned, 40% of them were fixed. 1 year later, 20 patients were stable and 2 patients were recurrent in 22 patients of the experiment group; in 24 patients of the control group, 7 patients were stable, 10 patients had hypersplenia, 2 patients occurred hepatocarcinoma and 5 patients were recurrent. CONCLUSION: Effect of 654-2 injection and "Gan Xian Tui Huang Recipe" on hepatic fibrosis with intractable jaundice is significant.
Authors: Rolf Teschke; Albrecht Wolff; Christian Frenzel; Axel Eickhoff; Johannes Schulze Journal: World J Gastroenterol Date: 2015-04-21 Impact factor: 5.742