Literature DB >> 1453502

The preventive effect of radix Salciae miltiorrhizae on monocrotaline-induced pulmonary hypertension in rats.

H Y Wang1, D Y Che, W Y Li.   

Abstract

The preventive effect of Radix Salciae Miltiorrhizae (RSM) on pulmonary hypertension (PHT) and right ventricular hypertrophy (RVH) induced by monocrotaline (MCT) in rats was observed with the methods of measuring the right ventricular systolic pressure (PVSP), the ratio of the right ventricle to the left ventricle plus interventricular septum RV/(LV+S) and the pulmonary small artery morphological analysis. The results show that RSM can reduce the PHT, and prevent the RVH and the increase of the medial thickness of pulmonary small arteries. It can also prevent the endothelial cell injury produced by MCT. The pharmacological effects of RSM on pulmonary circulation were also discussed.

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Year:  1992        PMID： 1453502     DOI： 10.1007/bf02887813

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  8 in total

1.  Ventricular weight in cardiac hypertrophy.

Authors:  R M FULTON; E C HUTCHINSON; A M JONES
Journal:  Br Heart J       Date:  1952-07

2.  Cor pulmonale in rats.

Authors:  Y Hayashi; J F Hussa; J J Lalich
Journal:  Lab Invest       Date:  1967-06       Impact factor: 5.662

3.  Alterations in pulmonary alveoli after a single injection of monocrotaline.

Authors:  E Valdivia; J J Lalich; Y Hayashi; J Sonnad
Journal:  Arch Pathol       Date:  1967-07

4.  Monocrotaline-induced pulmonary endothelial dysfunction in rats.

Authors:  A Molteni; W F Ward; C H Ts'ao; C D Port; N H Solliday
Journal:  Proc Soc Exp Biol Med       Date:  1984-05

5.  Angiotensin converting enzyme activity and evolution of pulmonary vascular disease in rats with monocrotaline pulmonary hypertension.

Authors:  J M Kay; P M Keane; K L Suyama; D Gauthier
Journal:  Thorax       Date:  1982-02       Impact factor: 9.139

6.  Effects of monocrotaline pretreatment of rats on removal of 5-hydroxytryptamine and noradrenaline by perfused lung.

Authors:  C N Gillis; R J Huxtable; R A Roth
Journal:  Br J Pharmacol       Date:  1978-07       Impact factor: 8.739

7.  Development of Crotalaria pulmonary hypertension: hemodynamic and structural study.

Authors:  B Meyrick; W Gamble; L Reid
Journal:  Am J Physiol       Date:  1980-11

8.  Monocrotaline-induced cardiopulmonary injury in rats: modification by the nonthiol ACE inhibitors CGS13945 and CGS16617.

Authors:  A Molteni; W F Ward; C Ts'ao; N H Solliday
Journal:  Arch Int Pharmacodyn Ther       Date:  1988 Jan-Feb
  8 in total
  1 in total

1.  The inhibitory effect of radix Salviae miltiorrhizae on hypoxic structural remodeling of intra-acinar pulmonary arteries.

Authors:  S C Xi; D Y Che; W R Zhang
Journal:  J Tongji Med Univ       Date:  1994
  1 in total

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