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Literature DB >> 14532125

Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities.

Alexander Hoffmann¹, Thomas H Leung, David Baltimore.

Abstract

The NF-kappaB transcription factors consist of dimeric proteins of the Rel homology family. They activate many promoters containing highly divergent kappaB-site sequences. We have generated cell lines lacking individual and multiple NF-kappaB proteins and used them to establish interactions between components of the NF-kappaB-IkappaB signaling system. Functional compensation within the family of dimers was evident in knockout cell lines. Analysis of transiently transfected genes gave an impression of promiscuity that was not borne out by analysis of endogenous genes. Using TNFalpha as an inducer, a panel of endogenous genes showed a wide range of subunit specificities as well as highly variable kinetics of induction. Comparing the function and subunit specificity of genes with the sequence of the kappaB DNA-binding site we found little correlation, indicating that NF-kappaB family member specificity for endogenous promoters is not solely encoded by the kappaB site sequence itself.

Entities: Gene

Mesh：

Substances：

Year: 2003 PMID： 14532125 PMCID： PMC213788 DOI： 10.1093/emboj/cdg534

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

52 in total

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162 in total

1. NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2.

Authors: Valere Busuttil; Nathalie Droin; Laura McCormick; Francesca Bernassola; Eleonora Candi; Gerry Melino; Douglas R Green
Journal: Proc Natl Acad Sci U S A Date: 2010-10-04 Impact factor: 11.205

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Journal: J Cell Sci Date: 2016-02-12 Impact factor: 5.285

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Journal: Cell Rep Date: 2020-06-16 Impact factor: 9.423

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Authors: Yuan Liu; Yan Chen; Lu Wen; Guohui Cui
Journal: J Huazhong Univ Sci Technolog Med Sci Date: 2012-01-27