| Literature DB >> 1453183 |
Q Shi1, K Chen, T Fujioka, Y Kashiwada, J J Chang, M Kozuka, J R Estes, A T McPhail, D R McPhail, K H Lee.
Abstract
A new dammarane triterpene, polacandrin [1], has been isolated from Polanisia dodecandra. The structure of 1 was established as 1 beta, 3 alpha, 12 beta, 25-tetrahydroxy-20(S),24(S)-epoxydammarane by chemical and spectroscopic methods, which included the concerted application of a number of 2D nmr techniques that involved 1H-1H COSY, HETCOR, NOESY, and long-range HETCOR. Single-crystal X-ray analysis of polacandrin pentahydrate verified the complete structure and stereochemistry. Polacandrin showed potent cytotoxicities against KB (ED50 = 0.60 microgram/ml), P-388 (ED50 = 0.90 microgram/ml), and RPMI-7951 (ED50 = 0.62 microgram/ml) tumor cells.Entities:
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Year: 1992 PMID： 1453183 DOI： 10.1021/np50088a015
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050