Literature DB >> 14531461

Modified release bi-layered tablet of melatonin using beta-cyclodextrin.

A Kumar1, S P Agarwal, R Khanna.   

Abstract

A modified release bi-layered tablet of melatonin incorporating a fast release fraction consisting of melatonin-beta-cyclodextrin inclusion complex and a slow release fraction containing melatonin in HPMC K15M and Carbopol 971 P matrices was prepared. The formulation developed showed an initial burst followed by a near zero order release pattern for a period of 8 h. The drug content, physical characteristics and the release profile were unaffected after 3 months of an accelerated stability study at 40 degrees C and 75% relative humidity.

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Year:  2003        PMID： 14531461

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  7 in total

1.  Modified Release of the Pineal Hormone Melatonin from Matrix Tablets Containing Poly(L-lactic Acid) and Its PLA-co-PEAd and PLA-co-PBAd Copolymers.

Authors:  Marilena Vlachou; Angeliki Siamidi; Dionysia Anagnostopoulou; Evi Christodoulou; Nikolaos D Bikiaris
Journal:  Polymers (Basel)       Date:  2022-04-07       Impact factor: 4.967

2.  Design and in vitro evaluation of novel sustained-release double-layer tablets of lornoxicam: utility of cyclodextrin and xanthan gum combination.

Authors:  Yassin El-Said Hamza; Mona Hassan Aburahma
Journal:  AAPS PharmSciTech       Date:  2009-11-18       Impact factor: 3.246

Review 3.  Toxicology of Blister Agents: Is Melatonin a Potential Therapeutic Option?

Authors:  Alejandro Romero; Eva Ramos; Francisco López-Muñoz; Cristóbal De Los Ríos; Javier Egea; Emilio Gil-Martín; René Pita; Juan J Torrado; Dolores R Serrano; Antonio Juberias
Journal:  Diseases       Date:  2021-04-10

4.  Comparative In Vitro Controlled Release Studies on the Chronobiotic Hormone Melatonin from Cyclodextrins-Containing Matrices and Cyclodextrin: Melatonin Complexes.

Authors:  Marilena Vlachou; Marianna Papamichael; Angeliki Siamidi; Irene Fragouli; Pandelis A Afroudakis; Rodanthi Kompogennitaki; Yannis Dotsikas
Journal:  Int J Mol Sci       Date:  2017-07-28       Impact factor: 5.923

5.  Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery.

Authors:  Cristiane Rd Hoffmeister; Taís L Durli; Scheila R Schaffazick; Renata P Raffin; Eduardo A Bender; Ruy Cr Beck; Adriana R Pohlmann; Sílvia S Guterres
Journal:  Nanoscale Res Lett       Date:  2012-05-15       Impact factor: 4.703

6.  Formulation and evaluation of fixed-dose combination of bilayer gastroretentive matrix tablet containing atorvastatin as fast-release and atenolol as sustained-release.

Authors:  Sanjay Dey; Sankha Chattopadhyay; Bhaskar Mazumder
Journal:  Biomed Res Int       Date:  2014-01-02       Impact factor: 3.411

Review 7.  Melatonin/Cyclodextrin Inclusion Complexes: A Review.

Authors:  Aikaterini Sakellaropoulou; Angeliki Siamidi; Marilena Vlachou
Journal:  Molecules       Date:  2022-01-10       Impact factor: 4.411
  7 in total

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