Ya-Yu Wang1, Shih-Yi Lin. 1. Department of Family Medicine, Taichung Veterans General Hospital, National Yang-Ming University School of Medicine, National Chung-Hsing University, Taichung, Taiwan.
Abstract
OBJECTIVES: This study was conducted to investigate whether leptin is involved in the etiogenesis of hepatocellular carcinoma (HCC) in cirrhotic patients. METHODS: Thirty-one male cirrhotic patients with HCC, 26 male cirrhotic patients without HCC, and 25 control subjects were included in this study. Body fat mass (FM) was determined by bioelectrical impedance analysis, and serum leptin and hormone concentrations were measured by immunoassay. RESULTS: A significant correlation of serum leptin levels to FM was observed in both patient groups and control subjects (r = 0.760, p < 0.001; r = 0.520, p < 0.01; r = 0.460, p < 0.05, respectively). The serum leptin levels in cirrhotic patients with or without HCC were significantly higher than those in control subjects (6.0 +/- 1.1 vs. 6.1 +/- 0.6 vs. 3.8 +/- 0.3 ng/ml, p < 0.05), though their body FM was lower. Using a multiple logistic regression analysis, it was found that the odds ratio of serum leptin for HCC was 1.04 (95% CI 0.79-1.33) after adjustment of several known risk factors. CONCLUSIONS: Our study demonstrated that cirrhotic patients with or without HCC had increased serum leptin concentrations. However, leptin did not appear to be associated with the development of HCC in cirrhotic patients. Copyright 2003 S. Karger AG, Basel
OBJECTIVES: This study was conducted to investigate whether leptin is involved in the etiogenesis of hepatocellular carcinoma (HCC) in cirrhotic patients. METHODS: Thirty-one male cirrhotic patients with HCC, 26 male cirrhotic patients without HCC, and 25 control subjects were included in this study. Body fat mass (FM) was determined by bioelectrical impedance analysis, and serum leptin and hormone concentrations were measured by immunoassay. RESULTS: A significant correlation of serum leptin levels to FM was observed in both patient groups and control subjects (r = 0.760, p < 0.001; r = 0.520, p < 0.01; r = 0.460, p < 0.05, respectively). The serum leptin levels in cirrhotic patients with or without HCC were significantly higher than those in control subjects (6.0 +/- 1.1 vs. 6.1 +/- 0.6 vs. 3.8 +/- 0.3 ng/ml, p < 0.05), though their body FM was lower. Using a multiple logistic regression analysis, it was found that the odds ratio of serum leptin for HCC was 1.04 (95% CI 0.79-1.33) after adjustment of several known risk factors. CONCLUSIONS: Our study demonstrated that cirrhotic patients with or without HCC had increased serum leptin concentrations. However, leptin did not appear to be associated with the development of HCC in cirrhotic patients. Copyright 2003 S. Karger AG, Basel
Authors: Anca D Petrescu; Stephanie Grant; Elaina Williams; Su Yeon An; Nikhil Seth; Mark Shell; Tyson Amundsen; Christopher Tan; Yusra Nadeem; Matthew Tjahja; Lancaster Weld; Christopher S Chu; Julie Venter; Gabriel Frampton; Matthew McMillin; Sharon DeMorrow Journal: Am J Pathol Date: 2021-12-08 Impact factor: 4.307
Authors: Kyle J Thompson; Kwan N Lau; Sarah Johnson; John B Martinie; David A Iannitti; Iain H McKillop; David Sindram Journal: HPB (Oxford) Date: 2011-01-27 Impact factor: 3.647