Literature DB >> 14527666

Is there an evolutionary relationship between WARP (von Willebrand factor A-domain-related protein) and the FACIT and FACIT-like collagens?

Jamie Fitzgerald1, John F Bateman.   

Abstract

We suggest that there is an evolutionary relationship between von Willebrand factor A-domain-related protein (WARP), and the fibril-associated collagen with interrupted triple helix (FACIT) and FACIT-like subfamilies of collagens. Data from a comparison of amino acid sequences, domain organisation and chromosomal location are consistent with the hypothesis that WARP and these collagens share a common collagen ancestor. In support of this is the observation that the WARP 3' coding region is GC-rich suggesting that this may represent the remnant of a triple helix protein domain which WARP has 'lost' during evolution.

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Year:  2003        PMID: 14527666     DOI: 10.1016/s0014-5793(03)00968-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  1 in total

1.  Mice lacking the extracellular matrix protein WARP develop normally but have compromised peripheral nerve structure and function.

Authors:  Justin M Allen; Laura Zamurs; Bent Brachvogel; Ursula Schlötzer-Schrehardt; Uwe Hansen; Shireen R Lamandé; Lynn Rowley; Jamie Fitzgerald; John F Bateman
Journal:  J Biol Chem       Date:  2009-03-11       Impact factor: 5.157

  1 in total

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