Literature DB >> 14526375

The production of recombinant pharmaceutical proteins in plants.

Julian K-C Ma1, Pascal M W Drake, Paul Christou.   

Abstract

Imagine a world in which any protein, either naturally occurring or designed by man, could be produced safely, inexpensively and in almost unlimited quantities using only simple nutrients, water and sunlight. This could one day become reality as we learn to harness the power of plants for the production of recombinant proteins on an agricultural scale. Molecular farming in plants has already proven to be a successful way of producing a range of technical proteins. The first plant-derived recombinant pharmaceutical proteins are now approaching commercial approval, and many more are expected to follow.

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Year:  2003        PMID: 14526375     DOI: 10.1038/nrg1177

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN: 1471-0056            Impact factor:   53.242


  181 in total

1.  Synthesis and expression of recombinant interferon alpha-5 gene in tobacco chloroplasts, a non-edible plant.

Authors:  Muhammad Sarwar Khan; Farwa Nurjis
Journal:  Mol Biol Rep       Date:  2011-09-22       Impact factor: 2.316

Review 2.  Promoter diversity in multigene transformation.

Authors:  Ariadna Peremarti; Richard M Twyman; Sonia Gómez-Galera; Shaista Naqvi; Gemma Farré; Maite Sabalza; Bruna Miralpeix; Svetlana Dashevskaya; Dawei Yuan; Koreen Ramessar; Paul Christou; Changfu Zhu; Ludovic Bassie; Teresa Capell
Journal:  Plant Mol Biol       Date:  2010-03-31       Impact factor: 4.076

3.  Amplicon-plus targeting technology (APTT) for rapid production of a highly unstable vaccine protein in tobacco plants.

Authors:  Kasi Azhakanandam; Sandra M Weissinger; Jennifer S Nicholson; Rongda Qu; Arthur K Weissinger
Journal:  Plant Mol Biol       Date:  2007-01-14       Impact factor: 4.076

Review 4.  Monoclonal antibody form and function: manufacturing the right antibodies for treating drug abuse.

Authors:  Eric Peterson; S Michael Owens; Ralph L Henry
Journal:  AAPS J       Date:  2006-05-26       Impact factor: 4.009

5.  Different subcellular localization and glycosylation for a functional antibody expressed in Nicotiana tabacum plants and suspension cells.

Authors:  Benoit De Muynck; Catherine Navarre; Yannick Nizet; Johannes Stadlmann; Marc Boutry
Journal:  Transgenic Res       Date:  2009-01-14       Impact factor: 2.788

6.  Stable mitotic inheritance of rice minichromosomes in cell suspension cultures.

Authors:  Xiaoyu Yang; Jianhui Li; Lei Chen; Eliezer S Louzada; Junxian He; Weichang Yu
Journal:  Plant Cell Rep       Date:  2015-02-03       Impact factor: 4.570

7.  Hydrophobin fusions for high-level transient protein expression and purification in Nicotiana benthamiana.

Authors:  Jussi J Joensuu; Andrew J Conley; Michael Lienemann; Jim E Brandle; Markus B Linder; Rima Menassa
Journal:  Plant Physiol       Date:  2009-12-11       Impact factor: 8.340

8.  Extremely high-level and rapid transient protein production in plants without the use of viral replication.

Authors:  Frank Sainsbury; George P Lomonossoff
Journal:  Plant Physiol       Date:  2008-09-05       Impact factor: 8.340

9.  Expression of recombinant antibody (single chain antibody fragment) in transgenic plant Nicotiana tabacum cv. Xanthi.

Authors:  S Dobhal; V K Chaudhary; A Singh; D Pandey; A Kumar; S Agrawal
Journal:  Mol Biol Rep       Date:  2013-11-12       Impact factor: 2.316

Review 10.  Anti-Ebola therapies based on monoclonal antibodies: current state and challenges ahead.

Authors:  Everardo González-González; Mario Moisés Alvarez; Alan Roberto Márquez-Ipiña; Grissel Trujillo-de Santiago; Luis Mario Rodríguez-Martínez; Nasim Annabi; Ali Khademhosseini
Journal:  Crit Rev Biotechnol       Date:  2015-11-26       Impact factor: 8.429

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