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Literature DB >> 14526373

From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family.

Abstract

Transforming growth factor-beta (TGF-beta) regulates many cellular processes through complex signal-transduction pathways that have crucial roles in normal development. Disruption of these pathways can lead to a range of diseases, including cancer. Mutations in the genes that encode members of the TGF-beta pathway are involved in vascular diseases as well as gastrointestinal neoplasia. More recently, they have been implicated in Cowden syndrome, which is normally associated with mutations in the phosphatase and tensin homologue gene PTEN. Molecular studies of TGF-beta signalling are now showing why mutations in genes that encode components of this pathway result in inherited cancer and developmental diseases.

Entities: Disease Gene Mutation

Mesh：

Substances：

Year: 2003 PMID： 14526373 DOI： 10.1038/nrg1178

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

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Cited

88 in total

1. Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer.

Authors: Xiyun Deng; Yanna Cao; Yan Liu; Fazhi Li; Kamalanathan Sambandam; Srinivasan Rajaraman; Archibald S Perkins; Alan P Fields; Mark R Hellmich; Courtney M Townsend; E Aubrey Thompson; Tien C Ko
Journal: Mol Carcinog Date: 2011-12-07 Impact factor: 4.784

2. Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression.

Authors: Mahta Nili; Ujwal Shinde; Peter Rotwein
Journal: J Biol Chem Date: 2010-06-08 Impact factor: 5.157

3. Another twist in the transforming growth factor beta-induced cell-cycle arrest chronicle.

Authors: Catherine Denicourt; Steven F Dowdy
Journal: Proc Natl Acad Sci U S A Date: 2003-12-15 Impact factor: 11.205

Review 4. U2AF homology motifs: protein recognition in the RRM world.

Authors: Clara L Kielkopf; Stephan Lücke; Michael R Green
Journal: Genes Dev Date: 2004-07-01 Impact factor: 11.361

Review 5. [Tumor stem cell research - basis and challenge for diagnosis and therapy].

Authors: Heidrun Karlic; Harald Herrmann; Axel Schulenburg; Thomas W Grunt; Sylvia Laffer; Irina Mirkina; Rainer Hubmann; Medhat Shehata; Brigitte Marian; Edgar Selzer; Michael Pfeilstöcker; Elisabeth Pittermann; Ulrich Jäger; Hubert Pehamberger; Christoph Zielinski; Peter Valent
Journal: Wien Klin Wochenschr Date: 2010-07-22 Impact factor: 1.704

From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family.

1. Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer.

2. Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression.

3. Another twist in the transforming growth factor beta-induced cell-cycle arrest chronicle.

Review 4. U2AF homology motifs: protein recognition in the RRM world.

Review 5. [Tumor stem cell research - basis and challenge for diagnosis and therapy].

6. Peptide ligands that use a novel binding site to target both TGF-β receptors.

Review 7. PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects.

8. SMAD4 haploinsufficiency associates with augmented colonic inflammation in select humans and mice.

9. Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts.

Review 10. The DAN family: modulators of TGF-β signaling and beyond.