Literature DB >> 1452418

Retinal toxicity of intravitreal lazaroid (21-aminosteroid U75412E).

S A Cruz1, M Karaçorlu, G A Peyman.   

Abstract

The 21-aminosteroids or lazaroids are a novel series of compounds being developed for the acute treatment of traumatic or ischemic injury of the nervous system. These compounds were specifically designed to localize within cell membranes and inhibit lipid peroxidation reactions. In this study, 21-aminosteroid U75412E was injected into the vitreous body of rabbit eyes to evaluate its suitability for intraocular injection and its toxicity on intraocular tissues. Doses ranged from 20 micrograms to 200 micrograms. Retinal toxicity was determined through light and transmission electron microscopy and electroretinography. No retinal toxicity was noted in doses of 30 micrograms and below.

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Year:  1992        PMID： 1452418     DOI： 10.1007/bf00916434

Source DB:  PubMed          Journal:  Int Ophthalmol        ISSN： 0165-5701            Impact factor:   2.031


  25 in total

Review 1.  Vitamin E: interactions with free radicals and ascorbate.

Authors:  P B McCay
Journal:  Annu Rev Nutr       Date:  1985       Impact factor: 11.848

2.  Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.

Authors:  J M Braughler; J F Pregenzer; R L Chase; L A Duncan; E J Jacobsen; J M McCall
Journal:  J Biol Chem       Date:  1987-08-05       Impact factor: 5.157

3.  Novel membrane localized iron chelators as inhibitors of iron-dependent lipid peroxidation.

Authors:  J M Braughler; P S Burton; R L Chase; J F Pregenzer; E J Jacobsen; F J VanDoornik; J M Tustin; D E Ayer; G L Bundy
Journal:  Biochem Pharmacol       Date:  1988-10-15       Impact factor: 5.858

4.  Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue.

Authors:  E D Hall; J M Braughler
Journal:  Exp Neurol       Date:  1981-07       Impact factor: 5.330

5.  Role of monoamines in experimental spinal cord injury in rats. Relationship between Na+-K+-ATPase and lipid peroxidation.

Authors:  M Kurihara
Journal:  J Neurosurg       Date:  1985-05       Impact factor: 5.115

6.  Vitamin E remains the major lipid-soluble, chain-breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency.

Authors:  K U Ingold; A C Webb; D Witter; G W Burton; T A Metcalfe; D P Muller
Journal:  Arch Biochem Biophys       Date:  1987-11-15       Impact factor: 4.013

7.  Ascorbic acid inhibits the activity of polymorphonuclear leukocytes in inflamed ocular tissues.

Authors:  R N Williams; C A Paterson; K E Eakins; P Bhattacherjee
Journal:  Exp Eye Res       Date:  1984-09       Impact factor: 3.467

8.  Current application of "high-dose" steroid therapy for CNS injury. A pharmacological perspective.

Authors:  J M Braughler; E D Hall
Journal:  J Neurosurg       Date:  1985-06       Impact factor: 5.115

Review 9.  George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury.

Authors:  H A Kontos
Journal:  Circ Res       Date:  1985-10       Impact factor: 17.367

10.  A new 21-aminosteroid antioxidant lacking glucocorticoid activity stimulates adrenocorticotropin secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT-20) cells.

Authors:  J M Braughler; R L Chase; G L Neff; P A Yonkers; J S Day; E D Hall; V H Sethy; R A Lahti
Journal:  J Pharmacol Exp Ther       Date:  1988-02       Impact factor: 4.030
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