Literature DB >> 14523385

Roles of the NKG2D immunoreceptor and its ligands.

David H Raulet1.   

Abstract

According to present concepts, innate immunity is regulated by receptors that determine danger levels by responding to molecules that are associated with infection or cellular distress. NKG2D is, perhaps, the best characterized receptor that is associated with responses to cellular distress, defined as transformation, infection or cell stress. This review summarizes recent findings that concern NKG2D, its ligands, its signalling properties and its role in disease, and provides a framework for considering how the induction of immune responses can be regulated by cellular responses to injury.

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Year:  2003        PMID: 14523385     DOI: 10.1038/nri1199

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN: 1474-1733            Impact factor:   53.106


  491 in total

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Journal:  J Immunol       Date:  2011-04-22       Impact factor: 5.422

7.  Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus.

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Journal:  Oncoimmunology       Date:  2018-02-08       Impact factor: 8.110

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10.  A selective role of NKG2D in inflammatory and autoimmune diseases.

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