| Literature DB >> 14523035 |
Abstract
Glycemic control is the primary mediator of diabetic microvascular complications and also contributes to macrovascular complications. A new study (see related article beginning on page 1049) reveals a previously unrecognized association between oxidant activation of poly(ADP ribose) polymerase (PARP) and upregulation of known mediators of glycemic injury. Inhibitors of PARP may have potential therapeutic roles in the prevention of diabetic complications.Entities:
Mesh:
Substances:
Year: 2003 PMID: 14523035 PMCID: PMC198532 DOI: 10.1172/JCI19902
Source DB: PubMed Journal: J Clin Invest ISSN: 0021-9738 Impact factor: 14.808