Literature DB >> 14523033

Selectin and selectin ligand binding: a bittersweet attraction.

Thomas M Zollner1, Khusru Asadullah.   

Abstract

Inhibition of leukocyte migration into target organs has long been an attractive, though challenging, basis for anti-inflammatory strategies. However, to date, the manipulation of leukocyte rolling along blood vessels has not yielded successful new therapies. An important study may now open new avenues in this exciting field of anti-inflammatory therapies by introducing a putative inhibitor of poly-N-acetyllactosamine biosynthesis that affects selectin ligand activity and shows efficacy in a rodent skin inflammation model.

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Year:  2003        PMID： 14523033      PMCID： PMC198533          DOI： 10.1172/JCI19962

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  16 in total

Review 1.  Carbohydrate mimetics-based glycosyltransferase inhibitors.

Authors:  P Compain; O R Martin
Journal:  Bioorg Med Chem       Date:  2001-12       Impact factor: 3.641

2.  A Readily Available, Highly Potent E-Selectin Antagonist.

Authors:  Gebhard Thoma; Rolf Bänteli; Wolfgang Jahnke; John L. Magnani; John T. Patton
Journal:  Angew Chem Int Ed Engl       Date:  2001-10-01       Impact factor: 15.336

Review 3.  Role of fucosyltransferases in leukocyte trafficking: major impact for cutaneous immunity.

Authors:  Arndt J Schottelius; Alf Hamann; Khusru Asadullah
Journal:  Trends Immunol       Date:  2003-03       Impact factor: 16.687

Review 4.  The molecular basis of lymphocyte recruitment to the skin: clues for pathogenesis and selective therapies of inflammatory disorders.

Authors:  Michael P Schön; Thomas M Zollner; W Henning Boehncke
Journal:  J Invest Dermatol       Date:  2003-11       Impact factor: 8.551

5.  The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis.

Authors:  P Malý; A Thall; B Petryniak; C E Rogers; P L Smith; R M Marks; R J Kelly; K M Gersten; G Cheng; T L Saunders; S A Camper; R T Camphausen; F X Sullivan; Y Isogai; O Hindsgaul; U H von Andrian; J B Lowe
Journal:  Cell       Date:  1996-08-23       Impact factor: 41.582

6.  Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation.

Authors:  Michael P Schön; Thomas Krahn; Margarete Schön; Maria-L Rodriguez; Horst Antonicek; Jeanette E Schultz; Ralf J Ludwig; Thomas M Zollner; Erwin Bischoff; Klaus-D Bremm; Matthias Schramm; Kerstin Henninger; Roland Kaufmann; Harald P M Gollnick; Christina M Parker; W-Henning Boehncke
Journal:  Nat Med       Date:  2002-04       Impact factor: 53.440

7.  Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins.

Authors:  M A Labow; C R Norton; J M Rumberger; K M Lombard-Gillooly; D J Shuster; J Hubbard; R Bertko; P A Knaack; R W Terry; M L Harbison
Journal:  Immunity       Date:  1994-11       Impact factor: 31.745

8.  Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin.

Authors:  Charles J Dimitroff; Ralph J Bernacki; Robert Sackstein
Journal:  Blood       Date:  2002-09-05       Impact factor: 22.113

9.  Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen.

Authors:  Charles J Dimitroff; Thomas S Kupper; Robert Sackstein
Journal:  J Clin Invest       Date:  2003-10       Impact factor: 14.808

10.  Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes.

Authors:  G Smithson; C E Rogers; P L Smith; E P Scheidegger; B Petryniak; J T Myers; D S Kim; J W Homeister; J B Lowe
Journal:  J Exp Med       Date:  2001-09-03       Impact factor: 14.307
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  3 in total

1.  Blocking the adhesion cascade at the premetastatic niche for prevention of breast cancer metastasis.

Authors:  Shin-Ae Kang; Nafis Hasan; Aman P Mann; Wei Zheng; Lichao Zhao; Lynsie Morris; Weizhu Zhu; Yan D Zhao; K Stephen Suh; William C Dooley; David Volk; David G Gorenstein; Massimo Cristofanilli; Hallgeir Rui; Takemi Tanaka
Journal:  Mol Ther       Date:  2015-03-27       Impact factor: 11.454

2.  CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen.

Authors:  John J Osterholzer; Theresa Ames; Timothy Polak; Joanne Sonstein; Bethany B Moore; Stephen W Chensue; Galen B Toews; Jeffrey L Curtis
Journal:  J Immunol       Date:  2005-07-15       Impact factor: 5.422

3.  E-selectin Targeting PEGylated-thioaptamer Prevents Breast Cancer Metastases.

Authors:  Yoshihiro Morita; Mohamed Kamal; Shin-Ae Kang; Roy Zhang; Ganesh Lr Lokesh; Varatharasa Thiviyanathan; Nafis Hasan; Sukyung Woo; Daniel Zhao; Macall Leslie; Stephen Suh; Wajeeha Razaq; Hallgeir Rui; David G Gorenstein; David E Volk; Takemi Tanaka
Journal:  Mol Ther Nucleic Acids       Date:  2016-12-13       Impact factor: 8.886
  3 in total

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