Literature DB >> 14522408

Type II secretory phospholipase A2 in cardiovascular disease: a mediator in atherosclerosis and ischemic damage to cardiomyocytes?

Hans W M Niessen1, Paul A J Krijnen, Cees A Visser, Chris J L M Meijer, C Erik Hack.   

Abstract

Inflammatory reactions contribute to the pathogenesis of cardiovascular conditions such as atherosclerosis and ischemic damage in acute myocardial infarction (AMI). Among the mediators involved in inflammation are secretory phospholipase A2 group II (sPLA2-II) enzymes. Though some cells constitutively express sPLA2-II, the synthesis by cells such as hepatocytes is typical for an acute-phase reactant. Recent literature suggests multiple roles for sPLA2-II in cardiovascular disease. In this review we discuss the role of sPLA2-II in various in vivo and in vitro models of atherosclerosis or AMI, including the therapeutic perspective of sPLA2-II inhibitors. It was concluded that sPLA2-II appears to be an important inflammatory mediator of cardiovascular disease.

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Year:  2003        PMID： 14522408     DOI： 10.1016/s0008-6363(03)00324-9

Source DB:  PubMed          Journal:  Cardiovasc Res        ISSN： 0008-6363            Impact factor:   10.787


  17 in total

1.  Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.

Authors:  Jun Saegusa; Nobuaki Akakura; Chun-Yi Wu; Case Hoogland; Zi Ma; Kit S Lam; Fu-Tong Liu; Yoko K Takada; Yoshikazu Takada
Journal:  J Biol Chem       Date:  2008-07-17       Impact factor: 5.157

2.  Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins αvβ3, α4β1, and α5β1.

Authors:  Masaaki Fujita; Kan Zhu; Chitose K Fujita; Min Zhao; Kit S Lam; Mark J Kurth; Yoko K Takada; Yoshikazu Takada
Journal:  J Biol Chem       Date:  2014-11-14       Impact factor: 5.157

3.  Combination diagnosis of multi-slice spiral computed tomography and secretary phospholipase A2-IIa for solitary pulmonary nodules.

Authors:  Hongjun Hou; Zushan Xu; Hongsheng Zhang; Yan Xu
Journal:  J Clin Lab Anal       Date:  2017-05-11       Impact factor: 2.352

4.  Astrocytes regulate α-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: Involvement of group IIA secretory phospholipase A2.

Authors:  X Yang; W Sheng; D M Ridgley; M A Haidekker; G Y Sun; J C Lee
Journal:  Neuroscience       Date:  2015-05-30       Impact factor: 3.590

5.  The catalytically active secretory phospholipase A2 type IIA is involved in restenosis development after PTCA in human coronary arteries and generation of atherogenic LDL.

Authors:  Aleksandra A Korotaeva; Elena V Samoilova; Aleksander I Kaminny; Aleksandra A Pirkova; Therese J Resink; Paul Erne; Nina V Prokazova; Vsevolod A Tkachuk; Evgeny I Chazov
Journal:  Mol Cell Biochem       Date:  2005-02       Impact factor: 3.396

6.  Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin αvβ3.

Authors:  Long Ye; Tiffany Dickerson; Handeep Kaur; Yoko K Takada; Masaaki Fujita; Ruiwu Liu; John M Knapp; Kit S Lam; Neil E Schore; Mark J Kurth; Yoshikazu Takada
Journal:  Bioorg Med Chem Lett       Date:  2012-10-24       Impact factor: 2.823

7.  Quantum dot cluster (QDC)-loaded phospholipid micelles as a FRET probe for phospholipase A2 detection.

Authors:  Junling Li; Yonghua Zhang; Junjie Ai; Qiang Gao; Honglan Qi; Chengxiao Zhang; Zhiliang Cheng
Journal:  RSC Adv       Date:  2016-02-01       Impact factor: 3.361

8.  Cl- channels are expressed in human normal monocytes: a functional role in migration, adhesion and volume change.

Authors:  M-J Kim; G Cheng; D K Agrawal
Journal:  Clin Exp Immunol       Date:  2004-12       Impact factor: 4.330

Review 9.  Acute phase reactants as novel predictors of cardiovascular disease.

Authors:  M S Ahmed; A B Jadhav; A Hassan; Qing H Meng
Journal:  ISRN Inflamm       Date:  2012-05-06

Review 10.  The secretory phospholipase A2 group IIA: a missing link between inflammation, activated renin-angiotensin system, and atherogenesis?

Authors:  Dimitar Divchev; Bernhard Schieffer
Journal:  Vasc Health Risk Manag       Date:  2008
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