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Literature DB >> 14522148

The multiple personalities of h-channels.

Abstract

Concepts regarding the function of the hyperpolarization-activated current (Ih) in shaping the excitability of single cells and neuronal ensembles have been evolving rapidly following the recent cloning of genes that encode the underlying 'h-channels' - the HCN genes. This article reviews new information about the transcriptional regulation of these channels, highlighting novel studies that demonstrate short- and long-term modulation of HCN expression, and linking this modulation to mechanisms of neurological diseases.

Entities: Disease Gene

Mesh：

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Year: 2003 PMID： 14522148 PMCID： PMC2924161 DOI： 10.1016/j.tins.2003.08.003

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

34 in total

1. Site independence of EPSP time course is mediated by dendritic I(h) in neocortical pyramidal neurons.

Authors: S R Williams; G J Stuart
Journal: J Neurophysiol Date: 2000-05 Impact factor: 2.714

Review 2. Emerging rules for the distributions of active dendritic conductances.

Authors: Michele Migliore; Gordon M Shepherd
Journal: Nat Rev Neurosci Date: 2002-05 Impact factor: 34.870

3. Single-cell mRNA expression of HCN1 correlates with a fast gating phenotype of hyperpolarization-activated cyclic nucleotide-gated ion channels (Ih) in central neurons.

Authors: O Franz; B Liss; A Neu; J Roeper
Journal: Eur J Neurosci Date: 2000-08 Impact factor: 3.386

Review 4. Pacemaker mechanisms in cardiac tissue.

Authors: D DiFrancesco
Journal: Annu Rev Physiol Date: 1993 Impact factor: 19.318

Review 5. Dynamic regulation of K+ channel gene expression in differentiated cells.

Authors: E S Levitan; K Takimoto
Journal: J Neurobiol Date: 1998-10

6. Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability.

Authors: K Chen; I Aradi; N Thon; M Eghbal-Ahmadi; T Z Baram; I Soltesz
Journal: Nat Med Date: 2001-03 Impact factor: 53.440

7. How does adrenaline accelerate the heart?

Authors: H F Brown; D DiFrancesco; S J Noble
Journal: Nature Date: 1979-07-19 Impact factor: 49.962

8. Does the "pacemaker current" generate the diastolic depolarization in the rabbit SA node cells?

Authors: A Noma; M Morad; H Irisawa
Journal: Pflugers Arch Date: 1983-05 Impact factor: 3.657

9. Voltage-clamp investigations of membrane currents underlying pace-maker activity in rabbit sino-atrial node.

Authors: H Brown; D Difrancesco
Journal: J Physiol Date: 1980-11 Impact factor: 5.182

10. Differential distribution of four hyperpolarization-activated cation channels in mouse brain.

Authors: S Moosmang; M Biel; F Hofmann; A Ludwig
Journal: Biol Chem Date: 1999 Jul-Aug Impact factor: 3.915

55 in total

1. Functional impact of the hyperpolarization-activated current on the excitability of myelinated A-type vagal afferent neurons in the rat.

Authors: Yu-Hong Zhou; Li-Hua Sun; Zhen-Hong Liu; Guixue Bu; Xiao-Ping Pang; Shi-Chao Sun; Guo-Fen Qiao; Bai-Yan Li; John H Schild
Journal: Clin Exp Pharmacol Physiol Date: 2010-04-26 Impact factor: 2.557

2. Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy.

Authors: Rainer Surges; Maria Kukley; Amy Brewster; Christiane Rüschenschmidt; Johannes Schramm; Tallie Z Baram; Heinz Beck; Dirk Dietrich
Journal: Biochem Biophys Res Commun Date: 2012-03-03 Impact factor: 3.575

3. Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.

Authors: Marco Lolicato; Marco Nardini; Sabrina Gazzarrini; Stefan Möller; Daniela Bertinetti; Friedrich W Herberg; Martino Bolognesi; Holger Martin; Marina Fasolini; Jay A Bertrand; Cristina Arrigoni; Gerhard Thiel; Anna Moroni
Journal: J Biol Chem Date: 2011-10-17 Impact factor: 5.157

4. Activation of Ih and TTX-sensitive sodium current at subthreshold voltages during CA1 pyramidal neuron firing.

Authors: Jason Yamada-Hanff; Bruce P Bean
Journal: J Neurophysiol Date: 2015-08-19 Impact factor: 2.714

Review 5. Regulation of recombinant and native hyperpolarization-activated cation channels.

Authors: Samuel G A Frère; Mira Kuisle; Anita Lüthi
Journal: Mol Neurobiol Date: 2004-12 Impact factor: 5.590

6. Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function.

Authors: Roland A Bender; Rafael Galindo; Manuel Mameli; Rebeca Gonzalez-Vega; C Fernando Valenzuela; Tallie Z Baram
Journal: Eur J Neurosci Date: 2005-11 Impact factor: 3.386

7. Single channel properties of hyperpolarization-activated cation currents in acutely dissociated rat hippocampal neurones.

Authors: T A Simeone; J M Rho; T Z Baram
Journal: J Physiol Date: 2005-08-25 Impact factor: 5.182

8. Hyperpolarization-activated currents are differentially expressed in mice brainstem auditory nuclei.

Authors: Katarina E Leao; Richardson N Leao; Hong Sun; Robert E W Fyffe; Bruce Walmsley
Journal: J Physiol Date: 2006-08-17 Impact factor: 5.182

9. Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices.

Authors: Joseph M Amatrudo; Christina M Weaver; Johanna L Crimins; Patrick R Hof; Douglas L Rosene; Jennifer I Luebke
Journal: J Neurosci Date: 2012-10-03 Impact factor: 6.167

10. Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation.

Authors: Qinqin Zha; Amy L Brewster; Cristina Richichi; Roland A Bender; Tallie Z Baram
Journal: J Neurochem Date: 2007-11-05 Impact factor: 5.372