| Literature DB >> 14521909 |
Koji Wakimoto1, Hiroaki Chiba, Hideo Michibata, Mariko Seishima, Satoshi Kawasaki, Kousaku Okubo, Hiroshi Mitsui, Hideshi Torii, Yuji Imai.
Abstract
Psoriasis is a skin disease with epidermal keratinocyte hyperproliferation and altered differentiation. To identify novel psoriasis-related genes, we investigated differentially expressed genes between normal and psoriatic skin. We identified a novel acyl CoA:diacylglycerol acyltransferase 2 (DGAT2) gene, which was decreased in human psoriatic skin. DGAT2 mRNA was expressed in sebaceous glands of normal human skin. DGAT2 protein was detected on endoplasmic reticulum. DGAT2 catalyzes the final step in the production of triglycerides and the accumulation of triglycerides in the tissues is considered to be related to insulin resistance. Therefore, we also investigated the expression of the DGAT2 gene in diabetic mice. DGAT2 mRNA was increased in the adipose, small intestine, and skeletal muscle in diabetic mice.Entities:
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Year: 2003 PMID： 14521909 DOI： 10.1016/j.bbrc.2003.09.015
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575