Literature DB >> 14519998

Fosmidomycin resistance in adenylate cyclase deficient (cya) mutants of Escherichia coli.

Yoshiko Sakamoto1, Soichi Furukawa, Hirokazu Ogihara, Makari Yamasaki.   

Abstract

Adenylate cyclase deficient (cya) mutants of E. coli K-12 were found to be resistant to fosmidomycin, a specific inhibitor of the non-mevalonate pathway, just like to fosfomycin. E. coli glpT mutants were resistant to fosfomycin and also to fosmidomycin. This fact shows that fosmidomycin was transported inside via the glycerol-3-phosphate transporter, GlpT. DNA micro-array analysis showed that the transcription of glpT and other genes concerning glycerol utilization were highly dependent on the presence of cAMP.

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Year:  2003        PMID： 14519998     DOI： 10.1271/bbb.67.2030

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  38 in total

1.  Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.

Authors:  Sara Sanders; Ryan J Vierling; David Bartee; Alicia A DeColli; Mackenzie J Harrison; Joseph L Aklinski; Andrew T Koppisch; Caren L Freel Meyers
Journal:  ACS Infect Dis       Date:  2017-06-21       Impact factor: 5.084

2.  Use of functional interactions with MarA to discover chromosomal genes affecting antibiotic susceptibility in Escherichia coli.

Authors:  Cristian Ruiz; Stuart B Levy
Journal:  Int J Antimicrob Agents       Date:  2010-12-23       Impact factor: 5.283

3.  1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin.

Authors:  Rakesh K Dhiman; Merrill L Schaeffer; Ann Marie Bailey; Charles A Testa; Hataichanok Scherman; Dean C Crick
Journal:  J Bacteriol       Date:  2005-12       Impact factor: 3.490

Review 4.  Resistance to antibiotics targeted to the bacterial cell wall.

Authors:  I Nikolaidis; S Favini-Stabile; A Dessen
Journal:  Protein Sci       Date:  2014-01-17       Impact factor: 6.725

5.  Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.

Authors:  Lisheng Deng; Jiasheng Diao; Pinhong Chen; Venugopal Pujari; Yuan Yao; Gang Cheng; Dean C Crick; B V Venkataram Prasad; Yongcheng Song
Journal:  J Med Chem       Date:  2011-06-02       Impact factor: 7.446

6.  Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli.

Authors:  Cristian Ruiz; Stuart B Levy
Journal:  Antimicrob Agents Chemother       Date:  2010-03-08       Impact factor: 5.191

7.  Genomic Deoxyxylulose Phosphate Reductoisomerase (DXR) Mutations Conferring Resistance to the Antimalarial Drug Fosmidomycin in E. coli.

Authors:  Gur Pines; Eun Joong Oh; Marcelo C Bassalo; Alaksh Choudhury; Andrew D Garst; Reilly G Fankhauser; Carrie A Eckert; Ryan T Gill
Journal:  ACS Synth Biol       Date:  2018-12-07       Impact factor: 5.110

8.  Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes.

Authors:  Lisheng Deng; Kiwamu Endo; Masahiro Kato; Gang Cheng; Shunsuke Yajima; Yongcheng Song
Journal:  ACS Med Chem Lett       Date:  2011-02-10       Impact factor: 4.345

9.  Capturing Functional Motions of Membrane Channels and Transporters with Molecular Dynamics Simulation.

Authors:  Saher Shaikh; Po-Chao Wen; Giray Enkavi; Zhijian Huang; Emad Tajkhorshid
Journal:  J Comput Theor Nanosci       Date:  2010-12

10.  Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.

Authors:  Lionel Kuntz; Denis Tritsch; Catherine Grosdemange-Billiard; Andréa Hemmerlin; Audrey Willem; Thomas J Bach; Michel Rohmer
Journal:  Biochem J       Date:  2005-02-15       Impact factor: 3.857
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