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Literature DB >> 14519549

Mesial temporal lobe epilepsy: a pathological replay of developmental mechanisms?

Ivan Cohen¹, Vincent Navarro, Caroline Le Duigou, Richard Miles.

Abstract

Focal epilepsies of the mesial temporal lobe are often associated with a hippocampal sclerosis. Changes in Cl homeostasis and GABAergic signalling in downstream regions, may contribute to the human pathology. A review of changes in cellular and synaptic function and connectivity after de-afferentation suggests this epileptic syndrome may involve a pathological replay of developmental mechanisms.

Entities: Disease Species

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Year: 2003 PMID： 14519549 DOI： 10.1016/s0248-4900(03)00081-9

Source DB: PubMed Journal: Biol Cell ISSN： 0248-4900 Impact factor: 4.458

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Cited

23 in total

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Review 2. Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII.

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Journal: J Physiol Date: 2004-11-04 Impact factor: 5.182

3. Recruitment of apical dendritic T-type Ca2+ channels by backpropagating spikes underlies de novo intrinsic bursting in hippocampal epileptogenesis.

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4. The dual roles of GABA in seizures and epilepsy generate more excitement.

Authors: Gregory C Mathews
Journal: Epilepsy Curr Date: 2007 Jan-Feb Impact factor: 7.500

5. The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus.

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Journal: J Physiol Date: 2010-03-08 Impact factor: 5.182

6. Spontaneous rhythmic field potentials of isolated mouse hippocampal-subicular-entorhinal cortices in vitro.

Authors: C P Wu; H L Huang; M Nassiri Asl; J W He; J Gillis; F K Skinner; L Zhang
Journal: J Physiol Date: 2006-08-03 Impact factor: 5.182

7. Depolarizing GABA acts on intrinsically bursting pyramidal neurons to drive giant depolarizing potentials in the immature hippocampus.

Authors: Sampsa T Sipilä; Kristiina Huttu; Ivan Soltesz; Juha Voipio; Kai Kaila
Journal: J Neurosci Date: 2005-06-01 Impact factor: 6.167