| Literature DB >> 14519389 |
Christopher V Carman1, Timothy A Springer.
Abstract
Integrins play critical roles in development, wound healing, immunity and cancer. Central to their function is their unique ability to modulate dynamically their adhesiveness through both affinity- and valency-based mechanisms. Recent advances have shed light on the structural basis for affinity regulation and on the signaling mechanisms responsible for both affinity and valency modes of regulation.Entities:
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Year: 2003 PMID： 14519389 DOI： 10.1016/j.ceb.2003.08.003
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382