| Literature DB >> 14517551 |
Valérie Pouillon1, Romana Hascakova-Bartova, Bernard Pajak, Emmanuelle Adam, Françoise Bex, Valérie Dewaste, Carine Van Lint, Oberdan Leo, Christophe Erneux, Stéphane Schurmans.
Abstract
Inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) is phosphorylated by Ins(1,4,5)P(3) 3-kinase, generating inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P(4)). The physiological function of Ins(1,3,4,5)P(4) is still unclear, but it has been reported to be a potential modulator of calcium mobilization. Disruption of the gene encoding the ubiquitously expressed Ins(1,4,5)P(3) 3-kinase isoform B (Itpkb) in mice caused a severe T cell deficiency due to major alterations in thymocyte responsiveness and selection. However, we were unable to detect substantial defects in Ins(1,4,5)P(3) amounts or calcium mobilization in Itpkb(-/-) thymocytes. These data indicate that Itpkb and Ins(1,3,4,5)P(4) define an essential signaling pathway for T cell precursor responsiveness and development.Entities:
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Year: 2003 PMID： 14517551 DOI： 10.1038/ni980
Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606