Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 D-cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task.

Literature DB >> 1451747

D-cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task.

Abstract

It is shown that D-cycloserine has cognition-enhancing properties in quinolinic acid hippocampal-lesioned rats. Lesioned rats had a severe impairment of working memory in an allocentric spatial reversal paradigm in the 8-arm maze, and performance could be restored with 12 mg/kg i.p. D-cycloserine, given 30 min before testing. The present findings favour the testing of D-cycloserine for clinical efficacy in patients with Alzheimer's disease with loss of pyramidal neurons and disconnected glycine-NMDA receptor activation.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1992 PMID： 1451747 DOI： 10.1016/0014-2999(92)94825-g

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

Keyword Cloud
Cited

20 in total

Review 1. Pharmacological treatments that facilitate extinction of fear: relevance to psychotherapy.

Authors: Michael Davis; Karyn M Myers; Jasmeer Chhatwal; Kerry J Ressler
Journal: NeuroRx Date: 2006-01

2. NMDA receptor and schizophrenia: a brief history.

Authors: Joseph T Coyle
Journal: Schizophr Bull Date: 2012-09 Impact factor: 9.306

Review 3. Could Dietary Glutamate Play a Role in Psychiatric Distress?

Authors: A Zarina Kraal; Nicole R Arvanitis; Andrew P Jaeger; Vicki L Ellingrod
Journal: Neuropsychobiology Date: 2019-01-30 Impact factor: 2.328

4. Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site.

Authors: Maja Jessen; Kristen Frederiksen; Feng Yi; Rasmus P Clausen; Kasper B Hansen; Hans Bräuner-Osborne; Paul Kilburn; Anders Damholt
Journal: Mol Pharmacol Date: 2017-06-06 Impact factor: 4.436

5. Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R-(+)-HA-966 in amygdala-kindled rats.

Authors: W Löscher; P Wlaź; C Rundfeldt; H Baran; D Hönack
Journal: Br J Pharmacol Date: 1994-05 Impact factor: 8.739

6. Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.

Authors: Hirosha Geekiyanage; Aditi Upadhye; Christina Chan
Journal: Neurobiol Aging Date: 2013-03-23 Impact factor: 4.673

D-cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task.

Review 1. Pharmacological treatments that facilitate extinction of fear: relevance to psychotherapy.

2. NMDA receptor and schizophrenia: a brief history.

Review 3. Could Dietary Glutamate Play a Role in Psychiatric Distress?

4. Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site.

5. Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R-(+)-HA-966 in amygdala-kindled rats.

6. Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.

Review 7. The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential.

8. D-cycloserine enhances short-delay, but not long-delay, conditioned taste aversion learning in rats.

Review 9. Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site.

Review 10. The Role of Serine Racemase in the Pathophysiology of Brain Disorders.