Literature DB >> 1451646

Phase I trial of cystemustine, a new cysteamine (2-chloroethyl) nitrosourea: an intrapatient escalation scheme.

G Mathé1, J L Misset, B K Triana, D Godenèche, J C Madelmont, G Meyniel.   

Abstract

A trial of cystemustine, a cysteamine nitrosourea, was carried out on 34 patients with advanced malignancies at increasing dosage of the drug over a period of up to 190 days in seven or eight cycles. A partial response to treatment was obtained in three patients. A degree of haematological toxicity developed in a number of the patients.

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Year:  1992        PMID: 1451646

Source DB:  PubMed          Journal:  Drugs Exp Clin Res        ISSN: 0378-6501


  1 in total

1.  Enhancement by O6-benzyl-N2-acetylguanosine of N'-[2-chloroethyl]-N-[2-(methylsulphonyl)ethyl]-N'-nitrosourea therapeutic index on nude mice bearing resistant human melanoma.

Authors:  E Debiton; C Cussac-Buchdhal; E Mounetou; M Rapp; J M Dupuy; J C Maurizis; A Veyre; J C Madelmont
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

  1 in total

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