Literature DB >> 14514940

Domiciliary non-invasive ventilation for recurrent acidotic exacerbations of COPD: an economic analysis.

J M Tuggey1, P K Plant, M W Elliott.   

Abstract

BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) pose a significant burden to healthcare providers with frequent exacerbations necessitating hospital admission. Randomised controlled data exist supporting the use of acute non-invasive ventilation (NIV) in patients with exacerbations of COPD with mild to moderate acidosis. The use of NIV is also described in chronic stable COPD, with evidence suggesting a reduction in hospital admissions and general practitioner care. We present economic data on the impact of domiciliary NIV on the need for admission to hospital and its attendant costs.
METHODS: A cost and consequences analysis of domiciliary NIV based on a before and after case note audit was performed in patients with recurrent acidotic exacerbations of COPD who tolerated and responded well to NIV. The primary outcome measure was the total cost incurred per patient per year from the perspective of the acute hospital. Effectiveness outcomes were total days in hospital and in intensive care.
RESULTS: Thirteen patients were identified. Provision of a home NIV service resulted in a mean (95% CI) saving of pound sterling 8254 (pound sterling 4013 to pound sterling 12,495) (Euro 11,720; Euro 5698 to Euro 17,743) per patient per year. Total days in hospital fell from a mean (SD) of 78 (51) to 25 (25) (p=0.004), number of admissions from 5 (3) to 2 (2) (p=0.007), and ICU days fell from a total of 25 to 4 (p=0.24). Outpatient visits fell from a mean of 5 (3) to 4 (2) (p=0.14).
CONCLUSIONS: This study suggests that domiciliary NIV for a highly selected group of COPD patients with recurrent admissions requiring NIV is effective at reducing admissions and minimises costs from the perspective of the acute hospital. Such evidence is important in obtaining financial support for providing such a service.

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Year:  2003        PMID: 14514940      PMCID: PMC1746494          DOI: 10.1136/thorax.58.10.867

Source DB:  PubMed          Journal:  Thorax        ISSN: 0040-6376            Impact factor:   9.139


  16 in total

1.  Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial.

Authors:  P K Plant; J L Owen; M W Elliott
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2.  Long-term controlled trial of nocturnal nasal positive pressure ventilation in patients with severe COPD.

Authors:  C Casanova; B R Celli; L Tost; E Soriano; J Abreu; V Velasco; F Santolaria
Journal:  Chest       Date:  2000-12       Impact factor: 9.410

3.  Non-invasive ventilation in acute exacerbations of chronic obstructive pulmonary disease: long term survival and predictors of in-hospital outcome.

Authors:  P K Plant; J L Owen; M W Elliott
Journal:  Thorax       Date:  2001-09       Impact factor: 9.139

4.  Cost effectiveness of ward based non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease: economic analysis of randomised controlled trial.

Authors:  P K Plant; J L Owen; S Parrott; M W Elliott
Journal:  BMJ       Date:  2003-05-03

5.  Nasal intermittent positive pressure ventilation. Long-term follow-up in patients with severe chronic respiratory insufficiency.

Authors:  P Leger; J M Bedicam; A Cornette; O Reybet-Degat; B Langevin; J M Polu; L Jeannin; D Robert
Journal:  Chest       Date:  1994-01       Impact factor: 9.410

6.  Randomised controlled trial of nasal ventilation in acute ventilatory failure due to chronic obstructive airways disease.

Authors:  J Bott; M P Carroll; J H Conway; S E Keilty; E M Ward; A M Brown; E A Paul; M W Elliott; R C Godfrey; J A Wedzicha; J Moxham
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7.  Randomized, prospective trial of noninvasive positive pressure ventilation in acute respiratory failure.

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Review 8.  Non-invasive positive pressure ventilation to treat respiratory failure resulting from exacerbations of chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis.

Authors:  Josephine V Lightowler; Jadwiga A Wedzicha; Mark W Elliott; Felix S F Ram
Journal:  BMJ       Date:  2003-01-25

9.  Noninvasive ventilation for acute respiratory failure: a prospective randomised placebo-controlled trial.

Authors:  F Thys; J Roeseler; M Reynaert; G Liistro; D O Rodenstein
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10.  The Italian multicentre study on noninvasive ventilation in chronic obstructive pulmonary disease patients.

Authors:  E Clini; C Sturani; A Rossi; S Viaggi; A Corrado; C F Donner; N Ambrosino
Journal:  Eur Respir J       Date:  2002-09       Impact factor: 16.671

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  23 in total

1.  Home mechanical ventilation: a Canadian Thoracic Society clinical practice guideline.

Authors:  Douglas A McKim; Jeremy Road; Monica Avendano; Steve Abdool; Fabien Cote; Nigel Duguid; Janet Fraser; Fracois Maltais; Debra L Morrison; Colleen O'Connell; Basil J Petrof; Karen Rimmer; Robert Skomro
Journal:  Can Respir J       Date:  2011 Jul-Aug       Impact factor: 2.409

Review 2.  COPD exacerbations. 4: Prevention.

Authors:  S Scott; P Walker; P M A Calverley
Journal:  Thorax       Date:  2006-05       Impact factor: 9.139

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Review 4.  [Noninvasive ventilation in patients with persistent hypercapnia].

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Review 5.  Chronic obstructive pulmonary disease: the clinical management of an acute exacerbation.

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Review 6.  The role of NIV in chronic hypercapnic COPD following an acute exacerbation: the importance of patient selection?

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7.  Monitoring Patient/Ventilator Interactions: Manufacturer's Perspective.

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Review 8.  Strategies for improving outcomes of COPD exacerbations.

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Review 9.  Current status of noninvasive ventilation in stable COPD patients.

Authors:  Salvador Díaz-Lobato; Sagrario Mayoralas Alises; Esteban Pérez Rodríguez
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2006

Review 10.  Treatment of respiratory failure in COPD.

Authors:  Stephan Budweiser; Rudolf A Jörres; Michael Pfeifer
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