Literature DB >> 14514791

Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle lymphoma with normal chromosomes 11 and 14.

A Aventín1, J Nomdedéu, J Briones, I Espinosa, R Bordes, J Sierra.   

Abstract

The t(11;14)(q13;q32) translocation is considered to be the cytogenetic hallmark of mantle cell lymphoma. This report describes a case of leukaemic mantle cell lymphoma in which conventional cytogenetics on stimulated peripheral blood cells showed a 46,XY, t(1;12)(p21;q23)/46,XY karyotype. Fluorescence in situ hybridisation analysis using a dual colour immunoglobulin heavy chain (IgH)/CCND1 probe showed a fusion hybridisation signal on one normal chromosome 14, indicating that an insertion of the CCND1 gene into the 14q32/IgH locus had taken place. Overexpression of the cyclin D1 protein was demonstrated on bone marrow trephine by immunohistochemical staining.

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Year:  2003        PMID： 14514791      PMCID： PMC1770075          DOI： 10.1136/jcp.56.10.798

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  10 in total

1.  Typical CBFbeta/MYH11 fusion due to insertion of the 3'-MYH11 gene into 16q22 in acute monocytic leukemia with normal chromosomes 16 and trisomies 8 and 22.

Authors:  A Aventín; R La Starza; J Nomdedéu; S Brunet; J Sierra; C Mecucci
Journal:  Cancer Genet Cytogenet       Date:  2000-12

2.  Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumor cell.

Authors:  A Gabrea; P L Bergsagel; M Chesi; Y Shou; W M Kuehl
Journal:  Mol Cell       Date:  1999-01       Impact factor: 17.970

3.  Detection of translocation t(11;14)(q13;q32) in mantle cell lymphoma by fluorescence in situ hybridization.

Authors:  J Y Li; F Gaillard; A Moreau; J L Harousseau; C Laboisse; N Milpied; R Bataille; H Avet-Loiseau
Journal:  Am J Pathol       Date:  1999-05       Impact factor: 4.307

4.  Identification of novel regions of amplification and deletion within mantle cell lymphoma DNA by comparative genomic hybridization.

Authors:  Jeannette E Allen; Rachael E Hough; John R Goepel; Sarah Bottomley; Gill A Wilson; Helen E Alcock; Margaret Baird; Paul C Lorigan; Elisabeth A Vandenberghe; Barry W Hancock; David W Hammond
Journal:  Br J Haematol       Date:  2002-02       Impact factor: 6.998

5.  Insertional events as well as translocations may arise during aberrant immunoglobulin switch recombination in a patient with multiple myeloma.

Authors:  G Pratt; J A Fenton; F E Davies; A C Rawstron; S J Richards; J E Collins; R G Owen; A S Jack; G M Smith; G J Morgan
Journal:  Br J Haematol       Date:  2001-02       Impact factor: 6.998

6.  Analysis of Philadelphia chromosome-negative BCR-ABL-positive chronic myelogenous leukemia by hypermetaphase fluorescence in situ hybridization.

Authors:  D Seong; H M Kantarjian; M Albitar; R Arlinghaus; J Xu; M Talpaz; M B Rios; J Q Guo; S O'Brien; M Siciliano
Journal:  Ann Oncol       Date:  1999-08       Impact factor: 32.976

7.  World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997.

Authors:  N L Harris; E S Jaffe; J Diebold; G Flandrin; H K Muller-Hermelink; J Vardiman; T A Lister; C D Bloomfield
Journal:  J Clin Oncol       Date:  1999-12       Impact factor: 44.544

8.  Diagnostic utility of fluorescence in situ hybridization in mantle-cell lymphoma.

Authors:  E D Remstein; P J Kurtin; I Buño; R J Bailey; J Proffitt; W A Wyatt; C A Hanson; G W Dewald
Journal:  Br J Haematol       Date:  2000-09       Impact factor: 6.998

9.  Secondary chromosome changes in mantle cell lymphoma.

Authors:  I Wlodarska; S Pittaluga; A Hagemeijer; C De Wolf-Peeters; H Van Den Berghe
Journal:  Haematologica       Date:  1999-07       Impact factor: 9.941

10.  A comparative analysis of FISH, RT-PCR, PCR, and immunohistochemistry for the diagnosis of mantle cell lymphomas.

Authors:  Marc-Antoine Belaud-Rotureau; Marie Parrens; Pierre Dubus; Jean-Christophe Garroste; Antoine de Mascarel; Jean-Philippe Merlio
Journal:  Mod Pathol       Date:  2002-05       Impact factor: 7.842
  10 in total

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