OBJECTIVE: Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naive patients experiencing a first episode of psychosis, but it is unknown if these deficits predate illness onset. METHOD: The olfactory identification ability of 81 patients at ultra-high risk for psychosis was examined in relation to that of 31 healthy comparison subjects. Twenty-two of the ultra-high-risk patients (27.2%) later became psychotic, and 12 of these were diagnosed with a schizophrenia spectrum disorder. RESULTS: There was a significant impairment in olfactory identification ability in the ultra-high-risk group that later developed a schizophrenia spectrum disorder but not in any other group. CONCLUSIONS: These findings suggest that impairment of olfactory identification is a premorbid marker of transition to schizophrenia, but it is not predictive of psychotic illness more generally.
OBJECTIVE: Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naivepatients experiencing a first episode of psychosis, but it is unknown if these deficits predate illness onset. METHOD: The olfactory identification ability of 81 patients at ultra-high risk for psychosis was examined in relation to that of 31 healthy comparison subjects. Twenty-two of the ultra-high-risk patients (27.2%) later became psychotic, and 12 of these were diagnosed with a schizophrenia spectrum disorder. RESULTS: There was a significant impairment in olfactory identification ability in the ultra-high-risk group that later developed a schizophrenia spectrum disorder but not in any other group. CONCLUSIONS: These findings suggest that impairment of olfactory identification is a premorbid marker of transition to schizophrenia, but it is not predictive of psychotic illness more generally.
Authors: Larry J Seidman; Anthony J Giuliano; Eric C Meyer; Jean Addington; Kristin S Cadenhead; Tyrone D Cannon; Thomas H McGlashan; Diana O Perkins; Ming T Tsuang; Elaine F Walker; Scott W Woods; Carrie E Bearden; Bruce K Christensen; Keith Hawkins; Robert Heaton; Richard S E Keefe; Robert Heinssen; Barbara A Cornblatt Journal: Arch Gen Psychiatry Date: 2010-06
Authors: Vidyulata Kamath; Bruce I Turetsky; Monica E Calkins; Christian G Kohler; Catherine G Conroy; Karin Borgmann-Winter; Dana E Gatto; Raquel E Gur; Paul J Moberg Journal: World J Biol Psychiatry Date: 2011-11-10 Impact factor: 4.132
Authors: Bruce I Turetsky; Vidyulata Kamath; Monica E Calkins; Warrick J Brewer; Stephen J Wood; Christos Pantelis; Larry J Seidman; Dolores Malaspina; Kimberley P Good; Lili C Kopala; Paul J Moberg Journal: Schizophr Res Date: 2012-05-14 Impact factor: 4.939
Authors: Vidyulata Kamath; Paul J Moberg; Monica E Calkins; Karin Borgmann-Winter; Catherine G Conroy; Raquel E Gur; Christian G Kohler; Bruce I Turetsky Journal: Schizophr Res Date: 2012-04-25 Impact factor: 4.939
Authors: Vidyulata Kamath; Bruce I Turetsky; Sarah C Seligman; Dana M Marchetto; Jeffrey B Walker; Paul J Moberg Journal: Arch Clin Neuropsychol Date: 2013-03-28 Impact factor: 2.813