Literature DB >> 14513903

Xanthofulvin, a novel semaphorin inhibitor produced by a strain of Penicillium.

Kazuo Kumagai1, Nobuo Hosotani, Kaoru Kikuchi, Toru Kimura, Ikutaro Saji.   

Abstract

A new semaphorin inhibitor xanthofulvin was isolated from the cultured broth of a fungus Penicillium sp. SPF-3059 along with a known compound vinaxanthone by solvent extraction and bioassay-guided fractionation. The tautomeric structure of xanthofulvin was determined by spectroscopic analyses. The two compounds exhibited significant semaphorin inhibitory activity with IC50 values of 0.09 and 0.1 microg/ml, respectively, in semaphorin3A-induced growth cone collapse assay using cultured chick dorsal root ganglia neurons.

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Year:  2003        PMID： 14513903     DOI： 10.7164/antibiotics.56.610

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  12 in total

Review 1.  Neurotrophic natural products: chemistry and biology.

Authors:  Jing Xu; Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  Angew Chem Int Ed Engl       Date:  2013-12-18       Impact factor: 15.336

2.  Glycan-dependent binding of galectin-1 to neuropilin-1 promotes axonal regeneration after spinal cord injury.

Authors:  H R Quintá; J M Pasquini; G A Rabinovich; L A Pasquini
Journal:  Cell Death Differ       Date:  2014-02-21       Impact factor: 15.828

3.  Podocyte Shape Regulation by Semaphorin 3A and MICAL-1.

Authors:  Alda Tufro
Journal:  Methods Mol Biol       Date:  2017

4.  Semaphorin3a promotes advanced diabetic nephropathy.

Authors:  Pardeep K Aggarwal; Delma Veron; David B Thomas; Dionicio Siegel; Gilbert Moeckel; Michael Kashgarian; Alda Tufro
Journal:  Diabetes       Date:  2014-12-04       Impact factor: 9.461

Review 5.  A perspective on the role of class III semaphorin signaling in central nervous system trauma.

Authors:  Vasil Mecollari; Bart Nieuwenhuis; Joost Verhaagen
Journal:  Front Cell Neurosci       Date:  2014-10-27       Impact factor: 5.505

6.  The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model.

Authors:  Risa Yamazaki; Katsuya Yamazoe; Satoru Yoshida; Shin Hatou; Emi Inagaki; Hideyuki Okano; Kazuo Tsubota; Shigeto Shimmura
Journal:  Sci Rep       Date:  2017-11-14       Impact factor: 4.379

7.  Semaphorin3A-Inhibitor Ameliorates Doxorubicin-Induced Podocyte Injury.

Authors:  Yizhen Sang; Kenji Tsuji; Akiko Inoue-Torii; Kazuhiko Fukushima; Shinji Kitamura; Jun Wada
Journal:  Int J Mol Sci       Date:  2020-06-08       Impact factor: 5.923

8.  Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons.

Authors:  Evguenia Ivakhnitskaia; Matthew R Chin; Dionicio Siegel; Victor H Guaiquil
Journal:  Sci Rep       Date:  2021-06-21       Impact factor: 4.379

9.  The semaphorin 3A inhibitor SM-345431 accelerates peripheral nerve regeneration and sensitivity in a murine corneal transplantation model.

Authors:  Masahiro Omoto; Satoru Yoshida; Hideyuki Miyashita; Tetsuya Kawakita; Kenji Yoshida; Akiyoshi Kishino; Toru Kimura; Shinsuke Shibata; Kazuo Tsubota; Hideyuki Okano; Shigeto Shimmura
Journal:  PLoS One       Date:  2012-11-09       Impact factor: 3.240

10.  Identification of natural inhibitors of Entamoeba histolytica cysteine synthase from microbial secondary metabolites.

Authors:  Mihoko Mori; Ghulam Jeelani; Yui Masuda; Kazunari Sakai; Kumiko Tsukui; Danang Waluyo; Yoshio Watanabe; Kenichi Nonaka; Atsuko Matsumoto; Satoshi Ōmura; Tomoyoshi Nozaki; Kazuro Shiomi
Journal:  Front Microbiol       Date:  2015-09-14       Impact factor: 5.640
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