Literature DB >> 14512852

Protective effect of erythropoietin in neonatal hypoxic ischemia in mice.

Hiroko Matsushita1, Michael V Johnston, Mary S Lange, Mary Ann Wilson.   

Abstract

The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NFkappaB-immunoreactive neurons were observed in the injured areas; these areas were smaller in the erythropoietin group. To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice.

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Year:  2003        PMID： 14512852     DOI： 10.1097/00001756-200309150-00020

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  23 in total

1.  Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity.

Authors:  Zhao Zhong Chong; Faqi Li; Kenneth Maiese
Journal:  Curr Neurovasc Res       Date:  2005-12       Impact factor: 1.990

2.  Erythropoietin Treatment Exacerbates Moderate Injury after Hypoxia-Ischemia in Neonatal Superoxide Dismutase Transgenic Mice.

Authors:  R Ann Sheldon; Christine Windsor; Byong Sop Lee; Olatz Arteaga Cabeza; Donna M Ferriero
Journal:  Dev Neurosci       Date:  2017-04-27       Impact factor: 2.984

Review 3.  Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better?

Authors:  Zhao Zhong Chong; Faqi Li; Kenneth Maiese
Journal:  Curr Neurovasc Res       Date:  2005-01       Impact factor: 1.990

Review 4.  Cerebral palsy.

Authors:  Michael V Johnston; Alexander H Hoon
Journal:  Neuromolecular Med       Date:  2006       Impact factor: 3.843

Review 5.  Erythropoietin (epoetin) as a protective factor for the brain.

Authors:  Samit Malhotra; Sheetal Nijhawan; Daniel M Rosenbaum
Journal:  Curr Atheroscler Rep       Date:  2004-07       Impact factor: 5.113

6.  Partial white and grey matter protection with prolonged infusion of recombinant human erythropoietin after asphyxia in preterm fetal sheep.

Authors:  Guido Wassink; Joanne O Davidson; Simerdeep K Dhillon; Mhoyra Fraser; Robert Galinsky; Laura Bennet; Alistair J Gunn
Journal:  J Cereb Blood Flow Metab       Date:  2016-07-20       Impact factor: 6.200

Review 7.  Plasticity and injury in the developing brain.

Authors:  Michael V Johnston; Akira Ishida; Wako Nakajima Ishida; Hiroko Baber Matsushita; Akira Nishimura; Masahiro Tsuji
Journal:  Brain Dev       Date:  2008-05-19       Impact factor: 1.961

8.  Erythropoietin sustains cognitive function and brain volume after neonatal stroke.

Authors:  Fernando F Gonzalez; Regina Abel; C Robert Almli; Dezhi Mu; Michael Wendland; Donna M Ferriero
Journal:  Dev Neurosci       Date:  2009-08-11       Impact factor: 2.984

9.  HIF-1 alpha-deficient mice have increased brain injury after neonatal hypoxia-ischemia.

Authors:  R Ann Sheldon; Damjan Osredkar; Christina L Lee; Xiangning Jiang; Dezhi Mu; Donna M Ferriero
Journal:  Dev Neurosci       Date:  2009-08-11       Impact factor: 2.984

10.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors:  Douglas B Kell
Journal:  BMC Med Genomics       Date:  2009-01-08       Impact factor: 3.063
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