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Literature DB >> 14511952

Technical issues in construction of nucleic acid vaccines.

Abstract

Delivery of antigen-encoding genes by nucleic acid vaccine vectors offers tremendous advantages in power and flexibility over conventional antigen delivery systems. Of the many forms of nucleic acid vaccine that can be constructed, circular DNA plasmids are the simplest. In this article, we consider the components that make up a generic DNA plasmid vaccine. We discuss some of the issues encountered when optimizing these vectors to exploit their potential for in vivo expression and presentation of antigens and thereby maximizing the immune response.

Mesh：

Substances：
Antigens
Vaccines, DNA

Year: 2003 PMID： 14511952 DOI： 10.1016/s1046-2023(03)00134-8

Source DB: PubMed Journal: Methods ISSN： 1046-2023 Impact factor: 3.608

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Cited

11 in total

Review 1. Nonviral DNA vectors for immunization and therapy: design and methods for their obtention.

Authors: Ernesto G Rodríguez
Journal: J Mol Med (Berl) Date: 2004-06-03 Impact factor: 4.599

Review 2. Rational vector design for efficient non-viral gene delivery: challenges facing the use of plasmid DNA.

Authors: Juergen Mairhofer; Reingard Grabherr
Journal: Mol Biotechnol Date: 2008-06 Impact factor: 2.695

3. Construction of a Novel DNA Vaccine Candidate encoding LmSTI1-PpSP42 Fusion Protein from Leishmania major and Phlebotomus papatasi against Cutaneous Leishmaniasis.

Authors: Touraj Miandoabi; Fariborz Bahrami; Vahideh Moein Vaziri; Soheila Ajdary
Journal: Rep Biochem Mol Biol Date: 2018-10

4. Optimized Genetic Tools Allow the Biosynthesis of Glycocin F and Analogues Designed To Test the Roles of gcc Cluster Genes in Bacteriocin Production.

Authors: Brittany J Drummond; Trevor S Loo; Mark L Patchett; Gillian E Norris
Journal: J Bacteriol Date: 2021-03-08 Impact factor: 3.490

5. Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine.

Authors: Mingtao Zeng; Qingfu Xu; Md Elias; Michael E Pichichero; Lance L Simpson; Leonard A Smith
Journal: Vaccine Date: 2007-09-05 Impact factor: 3.641

6. Rational Development of A Polycistronic Plasmid with A CpG-Free Bacterial Backbone as A Potential Tool for Direct Reprogramming.

Authors: Kianoush Dormiani; Hamid Mir Mohammad Sadeghi; Hojjat Sadeghi-Aliabadi; Mahboobeh Forouzanfar; Hossein Baharvand; Kamran Ghaedi; Mohammad Hossein Nasr-Esfahani
Journal: Cell J Date: 2016-09-26 Impact factor: 2.479

Technical issues in construction of nucleic acid vaccines.

Review 1. Nonviral DNA vectors for immunization and therapy: design and methods for their obtention.

Review 2. Rational vector design for efficient non-viral gene delivery: challenges facing the use of plasmid DNA.

3. Construction of a Novel DNA Vaccine Candidate encoding LmSTI1-PpSP42 Fusion Protein from Leishmania major and Phlebotomus papatasi against Cutaneous Leishmaniasis.

4. Optimized Genetic Tools Allow the Biosynthesis of Glycocin F and Analogues Designed To Test the Roles of gcc Cluster Genes in Bacteriocin Production.

5. Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine.

6. Rational Development of A Polycistronic Plasmid with A CpG-Free Bacterial Backbone as A Potential Tool for Direct Reprogramming.

Review 7. Live Bacterial Vectors-A Promising DNA Vaccine Delivery System.

8. In vitro analysis of expression vectors for DNA vaccination of horses: the effect of a Kozak sequence.

9. DNA immunization as an efficient strategy for vaccination.

10. DNA vaccine constructs against enterovirus 71 elicit immune response in mice.