| Literature DB >> 14511930 |
Alexander M Scharko1, Scott B Perlman, Robert W Pyzalski, Franklin M Graziano, James Sosman, C David Pauza.
Abstract
Positron emission tomography with fluorine-18-deoxyglucose (FDG-PET) detects active lymphoid tissues during HIV-1 infection in man. We used FDG-PET to study anatomical correlates of HIV-1 infection in man. Whole-body FDG-PET images from 15 patients with HIV-1 showed distinct lymphoid tissue activation in the head and neck during acute disease, a generalised pattern of peripheral lymph-node activation at mid-stages, and involvement of abdominal lymph nodes during late disease. Unexpectedly, HIV-1 progression was evident by distinct anatomical correlates, suggesting that lymphoid tissues are engaged in a predictable sequence. Understanding the anatomy of HIV-1 infection could encourage use of surgical or radiological interventions to supplement chemotherapy.Entities:
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Year: 2003 PMID： 14511930 DOI： 10.1016/S0140-6736(03)14366-8
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321