Literature DB >> 14511440

Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels.

Marian Beekman1, Bastiaan T Heijmans, Nicholas G Martin, John B Whitfield, Nancy L Pedersen, Ulf DeFaire, Harold Snieder, Nico Lakenberg, Peter de Knijff, Rune R Frants, Gert Jan B van Ommen, Cornelis Kluft, George P Vogler, P Eline Slagboom, Dorret I Boomsma.   

Abstract

Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.

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Year:  2003        PMID： 14511440     DOI： 10.1375/136905203322296692

Source DB:  PubMed          Journal:  Twin Res        ISSN： 1369-0523


  5 in total

1.  HLA and genomewide allele sharing in dizygotic twins.

Authors:  Grant W Montgomery; Gu Zhu; Jouke Jan Hottenga; David L Duffy; Andrew C Heath; Dorret I Boomsma; Nicholas G Martin; Peter M Visscher
Journal:  Am J Hum Genet       Date:  2006-10-23       Impact factor: 11.025

2.  Genome-wide association study of height and body mass index in Australian twin families.

Authors:  Jimmy Z Liu; Sarah E Medland; Margaret J Wright; Anjali K Henders; Andrew C Heath; Pamela A F Madden; Alexis Duncan; Grant W Montgomery; Nicholas G Martin; Allan F McRae
Journal:  Twin Res Hum Genet       Date:  2010-04       Impact factor: 1.587

3.  Genome-wide linkage analysis for identifying quantitative trait loci involved in the regulation of lipoprotein a (Lpa) levels.

Authors:  Sonia López; Alfonso Buil; Jordi Ordoñez; Juan Carlos Souto; Laura Almasy; Mark Lathrop; John Blangero; Francisco Blanco-Vaca; Jordi Fontcuberta; José Manuel Soria
Journal:  Eur J Hum Genet       Date:  2008-06-18       Impact factor: 4.246

4.  A New Method for Detecting Associations with Rare Copy-Number Variants.

Authors:  Jung-Ying Tzeng; Patrik K E Magnusson; Patrick F Sullivan; Jin P Szatkiewicz
Journal:  PLoS Genet       Date:  2015-10-02       Impact factor: 5.917

5.  Association test using Copy Number Profile Curves (CONCUR) enhances power in rare copy number variant analysis.

Authors:  Amanda Brucker; Wenbin Lu; Rachel Marceau West; Qi-You Yu; Chuhsing Kate Hsiao; Tzu-Hung Hsiao; Ching-Heng Lin; Patrik K E Magnusson; Patrick F Sullivan; Jin P Szatkiewicz; Tzu-Pin Lu; Jung-Ying Tzeng
Journal:  PLoS Comput Biol       Date:  2020-05-04       Impact factor: 4.475
  5 in total

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