| Literature DB >> 14510617 |
Qiuyun Dai1, Fengyun Liu, Yanrong Zhou, Baisong Lu, Fang Yu, Peitang Huang.
Abstract
The synthesis and characterization of the conopeptide, SO-3, originally derived from Conus striatus is reported. It contains 25 amino acid residues and three disulfide bridges and manifests 72% sequence identity with MVIIA, an N-type Ca2+ channel inhibitor of high analgesic activity. We evaluated SO-3 in several mouse models of pain. The results indicate that SO-3 is a potent, nonaddictive, analgesic agent.Entities:
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Year: 2003 PMID： 14510617 DOI： 10.1021/np030099y
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050