| Literature DB >> 1450952 |
J C Vickers1, A Delacourte, J H Morrison.
Abstract
Transitional and end-stage forms of neurofibrillary tangles associated with normal aging and Alzheimer's disease were identified using thioflavine staining combined with tau and neurofilament protein immunofluorescence. Normal aging was marked by transitional pathology in layer II of the entorhinal cortex but no neurofibrillary tangles in prefrontal cortex, whereas, in Alzheimer's disease cases, layer II entorhinal neurons had progressed to end-stage neurofibrillary tangles and the prefrontal cortex contained a high representation of transitional forms of the neurofibrillary tangle.Entities:
Mesh：
Year: 1992 PMID： 1450952 DOI： 10.1016/0006-8993(92)91134-z
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252