Literature DB >> 1450936

Anticonvulsant effect of intranigral fluoxetine.

A Pasini1, A Tortorella, K Gale.   

Abstract

Bilateral focal injections of the serotonin uptake inhibitor, fluoxetine (1.75-7.0 nmol) into substantia nigra (SN) protected against convulsive seizures evoked by the focal injection of bicuculline methiodide into area tempestas, an epileptogenic site within the deep prepiriform cortex. Injection of fluoxetine unilaterally in SN or bilaterally into a site dorsal to SN was not anticonvulsant. Blockade of nigral gamma-aminobutyric acid (GABA) receptors with bicuculline in SN did not reverse the anticonvulsant action of intranigral fluoxetine. These data suggest that serotonergic transmission in SN exerts a seizure suppressing action which is independent of GABA transmission in SN.

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Year:  1992        PMID： 1450936     DOI： 10.1016/0006-8993(92)91320-e

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

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Review 8.  Bypassing the Blood-Brain Barrier: Direct Intracranial Drug Delivery in Epilepsies.

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  8 in total

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