Literature DB >> 14507179

One-pot two-step microwave-assisted reaction in constructing 4,5-disubstituted pyrazolopyrimidines.

Tom Y H Wu1, Peter G Schultz, Sheng Ding.   

Abstract

[reaction: see text] A microwave-assisted reaction was developed to facilitate the construction of 4,5-disubstituted pyrazolopyrimidines. This one-pot two-step process involves a sequential S(N)Ar displacement of the C4 chloro substituent with various anilines and amines, followed by a Suzuki coupling reaction with different boronic acids. Using microwave irradiation leads to high product conversion, low side product formation, and shorter reactions.

Entities:  

Year:  2003        PMID： 14507179     DOI： 10.1021/ol035226w

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Suzuki-Miyaura cross-coupling of unprotected, nitrogen-rich heterocycles: substrate scope and mechanistic investigation.

Authors:  M Alexander Düfert; Kelvin L Billingsley; Stephen L Buchwald
Journal:  J Am Chem Soc       Date:  2013-08-16       Impact factor: 15.419

2.  A diversity oriented, microwave assisted synthesis of N-substituted 2-hydro-4-amino-pyrido[2,3-d]pyrimidin-7(8H)-ones.

Authors:  Núria Mont; Jordi Teixidó; José I Borrell
Journal:  Mol Divers       Date:  2008-11-27       Impact factor: 2.943

3.  Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases.

Authors:  Michael Klein; Montse Morillas; Alexandre Vendrell; Lars Brive; Marinella Gebbia; Iain M Wallace; Guri Giaever; Corey Nislow; Francesc Posas; Morten Grøtli
Journal:  PLoS One       Date:  2011-06-17       Impact factor: 3.240

4.  A regioselective C7 bromination and C7 palladium-catalyzed Suzuki-Miyaura cross-coupling arylation of 4-substituted NH-free indazoles.

Authors:  Khalid Boujdi; Nabil El Brahmi; Jérôme Graton; Didier Dubreuil; Sylvain Collet; Monique Mathé-Allainmat; Mohamed Akssira; Jacques Lebreton; Saïd El Kazzouli
Journal:  RSC Adv       Date:  2021-02-10       Impact factor: 3.361

5.  Microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues.

Authors:  Andreas Lanver; Hans-Günther Schmalz
Journal:  Molecules       Date:  2005-02-28       Impact factor: 4.411
  5 in total

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