Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The role of COX-2 inhibitors in pain modulation.

Literature DB >> 14506906

The role of COX-2 inhibitors in pain modulation.

Frederic Camu¹, Lin Shi, Caroline Vanlersberghe.

Abstract

NSAIDs are the analgesics that are most commonly used world-wide. In the past few years, there have been significant advances in explaining the mechanism of action and clinical efficacy of the drugs belonging to this pharmacological family. Recent data relating to the role of cyclo-oxygenase (COX)-2 in the development of neuronal hyperexcitability and pain hypersensitivity have opened new perspectives in our understanding of the therapeutic effects of these drugs in several painful conditions. The main objective of this brief review is to deal with some physiopathological and pharmacological aspects concerning the role of NSAIDs, with special reference to COX-2 inhibitors, in the treatment of pain.

Entities: Disease Gene

Mesh：

Substances：

Year: 2003 PMID： 14506906 DOI： 10.2165/00003495-200363001-00002

Source DB: PubMed Journal: Drugs ISSN： 0012-6667 Impact factor: 9.546

46 in total

1. An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia.

Authors: N Laflamme; S Lacroix; S Rivest
Journal: J Neurosci Date: 1999-12-15 Impact factor: 6.167

2. Comparison of the efficacy and safety of etodolac and piroxicam in patients with rheumatoid arthritis. Etodolac Study 326 Rheumatoid Arthritis Investigators Group.

Authors: R Lightfoot
Journal: J Rheumatol Suppl Date: 1997-02

3. Spinal administration of prostaglandin E(2) or prostaglandin F(2alpha) primarily produces mechanical hyperalgesia that is mediated by nociceptive specific spinal dorsal horn neurons.

Authors: Meredith E Turnbach; D Seth Spraggins; Alan Randich
Journal: Pain Date: 2002-05 Impact factor: 6.961

4. Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts.

Authors: J A Di Battista; H Fahmi; Y He; M Zhang; J Martel-Pelletier; J P Pelletier
Journal: Clin Exp Rheumatol Date: 2001 Impact factor: 4.473

Review 5. Neuronal plasticity: increasing the gain in pain.

Authors: C J Woolf; M W Salter
Journal: Science Date: 2000-06-09 Impact factor: 47.728

6. Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation.

Authors: F Beiche; S Scheuerer; K Brune; G Geisslinger; M Goppelt-Struebe
Journal: FEBS Lett Date: 1996-07-22 Impact factor: 4.124

7. Nimesulide decreases superoxide production by inhibiting phosphodiesterase type IV.

Authors: M Bevilacqua; T Vago; G Baldi; E Renesto; F Dallegri; G Norbiato
Journal: Eur J Pharmacol Date: 1994-08-16 Impact factor: 4.432

8. Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells.

Authors: V Casolaro; S Meliota; O Marino; V Patella; A de Paulis; G Guidi; G Marone
Journal: J Pharmacol Exp Ther Date: 1993-12 Impact factor: 4.030

9. An analysis from clinico-epidemiological data of the principal adverse events from the COX-2 selective NSAID, nimesulide, with particular reference to hepatic injury.

Authors: K D Rainsford
Journal: Inflammopharmacology Date: 1998 Impact factor: 4.473

10. Activity of nimesulide on constitutive and inducible cyclooxygenases.

Authors: I A Tavares; P M Bishai; A Bennett
Journal: Arzneimittelforschung Date: 1995-10

8 in total

Review 1. Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain.

Authors: Marco Sisignano; Ralf Baron; Klaus Scholich; Gerd Geisslinger
Journal: Nat Rev Neurol Date: 2014-11-04 Impact factor: 42.937

2. Neutrophil-Derived COX-2 has a Key Role during Inflammatory Hyperalgesia.

Authors: Nathalia Santos Carvalho; Julia Borges Paes Lemes; Marco Pagliusi; Ana Carolina Dos Santos Machado; Kauê Franco Malange; Laís Passariello Pral; José Luís Fachi; Catarine Massucato Nishijima; Gilson Gonçalves Dos Santos; Claudia Herrera Tambeli; Cesar Renato Sartori; Marco Aurélio Ramirez Vinolo; Carlos Amilcar Parada
Journal: Inflammation Date: 2022-07-15 Impact factor: 4.657

Review 3. Prostanoid receptor antagonists: development strategies and therapeutic applications.

Authors: R L Jones; M A Giembycz; D F Woodward
Journal: Br J Pharmacol Date: 2009-07-15 Impact factor: 8.739

Review 4. Cellular mechanisms of estradiol-mediated masculinization of the brain.

Authors: Jaclyn M Schwarz; Margaret M McCarthy
Journal: J Steroid Biochem Mol Biol Date: 2008-03-08 Impact factor: 4.292

Review 5. Estradiol and the developing brain.

Authors: Margaret M McCarthy
Journal: Physiol Rev Date: 2008-01 Impact factor: 37.312

6. P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach.

Authors: France Massicot; Guillaume Hache; Ludivine David; Dominique Chen; Charlotte Leuxe; Laure Garnier-Legrand; Patrice Rat; Olivier Laprévote; François Coudoré
Journal: PLoS One Date: 2013-06-27 Impact factor: 3.240

7. The effect of β-adrenergic blockade and COX-2 inhibition on healing of colon, muscle, and skin in rats undergoing colonic anastomosis.

Authors: O Hazut; L Shaashua; M Benish; B Levi; L Sorski; B Benjamin; A Hoffman; O Zmora; S Ben-Eliyahu
Journal: Int J Clin Pharmacol Ther Date: 2011-09 Impact factor: 1.366

8. Genome-wide transcriptional profiling of skin and dorsal root ganglia after ultraviolet-B-induced inflammation.

Authors: John M Dawes; Ana Antunes-Martins; James R Perkins; Kathryn J Paterson; Marco Sisignano; Ramona Schmid; Werner Rust; Tobias Hildebrandt; Gerd Geisslinger; Christine Orengo; David L Bennett; Stephen B McMahon
Journal: PLoS One Date: 2014-04-14 Impact factor: 3.240

8 in total