Literature DB >> 14506477

Priming virulence factors for delivery into the host.

C Erec Stebbins1, Jorge E Galán.   

Abstract

Several medically important Gram-negative bacterial pathogens inject virulence factors into host cells through a type III secretion system and specialized bacterial chaperones are required for their effective delivery. Recent structural work shows that these chaperones maintain virulence factors in a partially non-globular conformation that is primed for unfolding and translocation through the 'injectisome'.

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Year:  2003        PMID： 14506477     DOI： 10.1038/nrm1201

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  30 in total

Review 1.  Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion.

Authors:  Harald Brüssow; Carlos Canchaya; Wolf-Dietrich Hardt
Journal:  Microbiol Mol Biol Rev       Date:  2004-09       Impact factor: 11.056

Review 2.  Process of protein transport by the type III secretion system.

Authors:  Partho Ghosh
Journal:  Microbiol Mol Biol Rev       Date:  2004-12       Impact factor: 11.056

3.  The flagellar-specific transcription factor, sigma28, is the Type III secretion chaperone for the flagellar-specific anti-sigma28 factor FlgM.

Authors:  Phillip D Aldridge; Joyce E Karlinsey; Christine Aldridge; Christopher Birchall; Danielle Thompson; Jin Yagasaki; Kelly T Hughes
Journal:  Genes Dev       Date:  2006-08-15       Impact factor: 11.361

4.  Optimization of the delivery of heterologous proteins by the Salmonella enterica serovar Typhimurium type III secretion system for vaccine development.

Authors:  Li-Mei Chen; Gabriel Briones; Ruben O Donis; Jorge E Galán
Journal:  Infect Immun       Date:  2006-10       Impact factor: 3.441

5.  Mapping of the chaperone AcrH binding regions of translocators AopB and AopD and characterization of oligomeric and metastable AcrH-AopB-AopD complexes in the type III secretion system of Aeromonas hydrophila.

Authors:  Yih Wan Tan; Hong Bing Yu; J Sivaraman; Ka Yin Leung; Yu-Keung Mok
Journal:  Protein Sci       Date:  2009-08       Impact factor: 6.725

6.  Structural insights on two hypothetical secretion chaperones from Xanthomonas axonopodis pv. citri.

Authors:  Juliana Fattori; Alessandra Prando; Leandro H P Assis; Ricardo Aparicio; Ljubica Tasic
Journal:  Protein J       Date:  2011-06       Impact factor: 2.371

7.  A Salmonella type three secretion effector/chaperone complex adopts a hexameric ring-like structure.

Authors:  Pierre Roblin; Frédérique Dewitte; Vincent Villeret; Emanuele G Biondi; Coralie Bompard
Journal:  J Bacteriol       Date:  2014-11-17       Impact factor: 3.490

8.  Structural Features Reminiscent of ATP-Driven Protein Translocases Are Essential for the Function of a Type III Secretion-Associated ATPase.

Authors:  Junya Kato; Matthew Lefebre; Jorge E Galán
Journal:  J Bacteriol       Date:  2015-07-13       Impact factor: 3.490

9.  Context-dependent protein folding of a virulence peptide in the bacterial and host environments: structure of an SycH-YopH chaperone-effector complex.

Authors:  Milos Vujanac; C Erec Stebbins
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2013-03-09

10.  Structural and biochemical characterization of SrcA, a multi-cargo type III secretion chaperone in Salmonella required for pathogenic association with a host.

Authors:  Colin A Cooper; Kun Zhang; Sara N Andres; Yuan Fang; Natalia A Kaniuk; Mandy Hannemann; John H Brumell; Leonard J Foster; Murray S Junop; Brian K Coombes
Journal:  PLoS Pathog       Date:  2010-02-05       Impact factor: 6.823
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