| Literature DB >> 14505676 |
Fei Liu1, Eric F Johnson, David J Austin, Karen S Anderson.
Abstract
A strategy of full-site occupancy and stereospecific recognition in the triphosphate subsite was used to specifically inhibit two protein kinases HER-2 and HER-4 from the EGFR family. The SAR profiles of a panel of adenosine-anchored bicyclic heterocycles against HER-2 and HER-4 indicated that specificity can be derived for highly homologous protein kinases from stereospecific recognition in the triphosphate-subsite.Entities:
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Year: 2003 PMID： 14505676 DOI： 10.1016/s0960-894x(03)00761-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823