Literature DB >> 14505673

Synthesis and in vitro analysis of atrial natriuretic peptide-albumin conjugates.

Roger Léger1, Martin Robitaille, Omar Quraishi, Elizabeth Denholm, Corinne Benquet, Julie Carette, Pieter van Wyk, Isabelle Pellerin, Nathalie Bousquet-Gagnon, Jean-Paul Castaigne, Dominique Bridon.   

Abstract

Atrial natriuretic peptide (ANP) is a clinically useful anti-hypertensive hormone. Maleimide derivatives of ANP have been synthesized and conjugated to cysteine-34 of human serum albumin. The conjugates were analyzed to assess their stability, receptor binding affinity and ability to stimulate guanylyl-cyclase activity in rat lung fibroblasts.

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Year:  2003        PMID： 14505673     DOI： 10.1016/s0960-894x(03)00790-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Preexposure prophylaxis with albumin-conjugated C34 peptide HIV-1 fusion inhibitor in SCID-hu Thy/Liv mice.

Authors:  Cheryl A Stoddart; Geneviève Nault; Sofiya A Galkina; Nathalie Bousquet-Gagnon; Dominique Bridon; Omar Quraishi
Journal:  Antimicrob Agents Chemother       Date:  2012-01-17       Impact factor: 5.191

2.  Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice.

Authors:  Cheryl A Stoddart; Geneviève Nault; Sofiya A Galkina; Karen Thibaudeau; Peter Bakis; Nathalie Bousquet-Gagnon; Martin Robitaille; Maryanne Bellomo; Véronique Paradis; Patricia Liscourt; Alexandra Lobach; Marie-Eve Rivard; Roger G Ptak; Marie K Mankowski; Dominique Bridon; Omar Quraishi
Journal:  J Biol Chem       Date:  2008-09-22       Impact factor: 5.157
  2 in total

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