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Literature DB >> 14505667

Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase.

Kamil Kuca¹, Jirí Bielavský, Jirí Cabal, Jirí Kassa.

Abstract

Synthesis of a new asymmetric bisquaternary reactivator of tabun-inhibited acetylcholinesterase-1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide is described. Reactivation potency of this oxime is compared to the currently used reactivators-pralidoxime, obidoxime and H-oxime HI-6.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2003 PMID： 14505667 DOI： 10.1016/s0960-894x(03)00751-0

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

15 in total

1. The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure.

Authors: Lucie Bartosova; Kamil Kuca; Gabriela Kunesova; Daniel Jun
Journal: Neurotox Res Date: 2006-06 Impact factor: 3.911

2. Cholinergic stimulation of the immune system protects against lethal infection by Salmonella enterica serovar Typhimurium.

Authors: Maria J Fernandez-Cabezudo; Dietrich E Lorke; Sheikh Azimullah; Milena Mechkarska; Mohammed Y Hasan; Georg A Petroianu; Basel K al-Ramadi
Journal: Immunology Date: 2010-04-08 Impact factor: 7.397

3. Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes.

Authors: Kamil Kuca; Jirí Patocka; Jirí Cabal; Daniel Jun
Journal: Neurotox Res Date: 2004 Impact factor: 3.911

4. Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.

Authors: Sandip B Bharate; Lilu Guo; Tony E Reeves; Douglas M Cerasoli; Charles M Thompson
Journal: Bioorg Med Chem Date: 2009-11-27 Impact factor: 3.641

5. The present approaches to the development of prophylactic and therapeutic antidotes against nerve agents.

Authors: Jiří Kassa; Jiří Bajgar; Kamil Kuča; Kamil Musílek; Jana Karasová
Journal: Interdiscip Toxicol Date: 2008-06

Review 6. Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.

Authors: Biljana Antonijevic; Milos P Stojiljkovic
Journal: Clin Med Res Date: 2007-03

7. The influence of oxime and anticholinergic drug selection on the potency of antidotal treatment to counteract acute toxic effects of tabun in mice.

Authors: Jirí Kassa
Journal: Neurotox Res Date: 2006-01 Impact factor: 3.911