| Literature DB >> 14505666 |
Ranjit C Desai1, Dominick F Gratale, Wei Han, Hiroo Koyama, Edward Metzger, Victoria K Lombardo, Karen L MacNaul, Thomas W Doebber, Joel P Berger, Kwan Leung, Ronald Franklin, David E Moller, James V Heck, Soumya P Sahoo.
Abstract
A series of novel aryloxazolidine-2,4-diones was synthesized. A structure-activity relationship study of these compounds led to the identification of potent, orally active PPAR dual alpha/gamma agonists. Based on the results of efficacy studies in the db/db mice model of type 2 diabetes and the desired pharmacokinetic parameters, compound 12 was selected for further profiling.Entities:
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Year: 2003 PMID： 14505666 DOI： 10.1016/s0960-894x(03)00785-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823