| Literature DB >> 14505664 |
Shu-Hui Chen1, Jason Lamar, Frantz Victor, Nancy Snyder, Robert Johnson, Beverly A Heinz, Mark Wakulchik, Q May Wang.
Abstract
We describe herein the synthesis and biological evaluation of a series of tripeptidyl alpha-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-14.Entities:
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Year: 2003 PMID： 14505664 DOI： 10.1016/s0960-894x(03)00753-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823