| Literature DB >> 14505660 |
Yonggang Li1, Yufang Xu, Xuhong Qian, Baoyuan Qu.
Abstract
A new family of photonuclease, thiadiazole-naphthalimide were synthesized and evaluated. Thiadiazole group was incorporated for the first time. These compounds intercalated into DNA efficiently and damaged DNA as low as 10 microM photochemically. Mechanism experiment showed that electron transfer and radicals were involved.Entities:
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Year: 2003 PMID： 14505660 DOI： 10.1016/s0960-894x(03)00737-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823