Literature DB >> 14505637

Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors.

Anthony K Ogawa1, Chris A Willoughby, Raynald Bergeron, Kenneth P Ellsworth, Wayne M Geissler, Robert W Myers, Jun Yao, Georgianna Harris, Kevin T Chapman.   

Abstract

The synthesis of a series of novel dihdyropyridine diacid glycogen phosphorylase inhibitors is presented. SAR and functional assay data are discussed, along with the effect of a single inhibitor on blood glucose in a diabetic animal model.

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Year:  2003        PMID： 14505637     DOI： 10.1016/s0960-894x(03)00798-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs.

Authors:  Tracy P Torres; Noriyasu Sasaki; E Patrick Donahue; Brooks Lacy; Richard L Printz; Alan D Cherrington; Judith L Treadway; Masakazu Shiota
Journal:  J Pharmacol Exp Ther       Date:  2011-03-01       Impact factor: 4.030

Review 2.  Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges.

Authors:  Imtiaz Khan; Aliya Ibrar; Sumera Zaib
Journal:  Top Curr Chem (Cham)       Date:  2021-01-05

3.  Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs.

Authors:  Nikos G Oikonomakos; Magda N Kosmopoulou; Evangelia D Chrysina; Demetres D Leonidas; Ioannis D Kostas; K Ulrich Wendt; Thomas Klabunde; Elisabeth Defossa
Journal:  Protein Sci       Date:  2005-07       Impact factor: 6.725

Review 4.  Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.

Authors:  Amy K Rines; Kfir Sharabi; Clint D J Tavares; Pere Puigserver
Journal:  Nat Rev Drug Discov       Date:  2016-08-12       Impact factor: 84.694

5.  FR258900, a potential anti-hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase.

Authors:  Costas Tiraidis; Kyra-Melinda Alexacou; Spyros E Zographos; Demetres D Leonidas; Thanasis Gimisis; Nikos G Oikonomakos
Journal:  Protein Sci       Date:  2007-06-28       Impact factor: 6.725

6.  Assessment of the Cytotoxic Effect of a Series of 1,4-Dihydropyridine Derivatives Against Human Cancer Cells.

Authors:  Nima Razzaghi-Asl; Ramin Miri; Omidreza Firuzi
Journal:  Iran J Pharm Res       Date:  2016       Impact factor: 1.696

7.  Metformin normalizes the structural changes in glycogen preceding prediabetes in mice overexpressing neuropeptide Y in noradrenergic neurons.

Authors:  Liisa Ailanen; Natalia N Bezborodkina; Laura Virtanen; Suvi T Ruohonen; Anastasia V Malova; Sergey V Okovityi; Elizaveta Y Chistyakova; Eriika Savontaus
Journal:  Pharmacol Res Perspect       Date:  2018-03-08
  7 in total

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