| Literature DB >> 14505383 |
Mukund P Sibi1, Narayanasamy Prabagaran, Sandeep G Ghorpade, Craig P Jasperse.
Abstract
Highly diastereoselective and enantioselective addition of N-benzylhydroxylamine to imides 17 and 20-30 produces alpha,beta-trans-disubstituted N-benzylisoxazolidinones 19 and 31-41. These reactions proceed in 60-96% ee with 93-99% de's using 5 mol % of Mg(NTf2)2 and ligand 18. The product isoxazolidinones can be hydrogenolyzed directly to provide alpha,beta-disubstituted-beta-amino acids.Entities:
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Year: 2003 PMID： 14505383 DOI： 10.1021/ja0372309
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419