OBJECTIVE: The aim of the present study was to examine the relationship between magnetic resonance imaging (MRI) findings and cognitive functioning in a group of patients with primary Sjögren Syndrome (SS). METHODS: Fifteen subjects with primary SS and fifteen control subjects diagnosed with migraine were assessed. All subjects received a detailed neuropsychological assessment especially sensitive to fronto-subcortical disorders and a MRI study. Volumetric measures of the ventricular system and intracranial volume and measures of the severity and distribution of signal hyperintensities were obtained. RESULTS: Patients with SS showed larger ventricular volume than control subjects with migraine. The severity of MRI signal hyperintensities and ventricular volume were related to several cognitive and psychiatric variables. CONCLUSION: Patients with primary SS have morphological abnormalities that are related to neuropsychological and psychiatric disturbances. These findings provide some support for the organic etiology of cognitive and psychiatric dysfunction and thus for central nervous system involvement in SS.
OBJECTIVE: The aim of the present study was to examine the relationship between magnetic resonance imaging (MRI) findings and cognitive functioning in a group of patients with primary Sjögren Syndrome (SS). METHODS: Fifteen subjects with primary SS and fifteen control subjects diagnosed with migraine were assessed. All subjects received a detailed neuropsychological assessment especially sensitive to fronto-subcortical disorders and a MRI study. Volumetric measures of the ventricular system and intracranial volume and measures of the severity and distribution of signal hyperintensities were obtained. RESULTS:Patients with SS showed larger ventricular volume than control subjects with migraine. The severity of MRI signal hyperintensities and ventricular volume were related to several cognitive and psychiatric variables. CONCLUSION:Patients with primary SS have morphological abnormalities that are related to neuropsychological and psychiatric disturbances. These findings provide some support for the organic etiology of cognitive and psychiatric dysfunction and thus for central nervous system involvement in SS.
Authors: Sandrine Indart; Jacques Hugon; Pierre Jean Guillausseau; Alice Gilbert; Julien Dumurgier; Claire Paquet; Damien Sène Journal: Medicine (Baltimore) Date: 2017-04 Impact factor: 1.889
Authors: Tabea Seeliger; Lena Jacobsen; Merle Hendel; Lena Bönig; Nils K Kristian Prenzler; Thea Thiele; Diana Ernst; Torsten Witte; Martin Stangel; Bruno Kopp; Thomas Skripuletz Journal: Ann Clin Transl Neurol Date: 2020-07-06 Impact factor: 4.511
Authors: Frederic Blanc; Nadine Longato; Barbara Jung; Catherine Kleitz; Laure Di Bitonto; Benjamin Cretin; Nicolas Collongues; Christelle Sordet; Marie Fleury; Vincent Poindron; Jacques-Eric Gottenberg; Olivier Anne; Dan Lipsker; Thierry Martin; Jean Sibilia; Jérôme de Seze Journal: ISRN Neurol Date: 2013-09-19